LETTER	Synlett 2007: 0407-0410   DOI: 10.1055/s-2007-967954
© Georg Thieme Verlag Stuttgart · New York
Oxidative Conversion of Primary Alcohols, and Primary, Secondary, and Tertiary Amines into the Corresponding Nitriles with 1,3-Diiodo-5,5-dimethylhydantoin in Aqueous NH3
Shinpei Iida, Hideo Togo*
Graduate School of Science and Technology, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan e-Mail: togo@faculty.chiba-u.jp;
Received 27 November 2006

Abstract

Various primary alcohols, and primary, secondary, and tertiary amines were oxidatively and efficiently converted into the corresponding nitriles in good yields, by 1,3-diiodo-5,5-dimethylhydantoin (DIH) in aqueous ammonia (NH₃) at 60 °C.

Key words

primary alcohols - primary amines - secondary amines - tertiary amines - 1,3-diiodo-5,5-dimethylhydantoin - nitriles - aqueous ammonia