LETTER	Synlett 2007: 0318-0320   DOI: 10.1055/s-2007-968008
© Georg Thieme Verlag Stuttgart · New York
Catalytic One-Pot, Three-Component Acyl-Strecker Reaction
Subhas Chandra Pan, Benjamin List*
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany Fax: +49(208)3062999; e-Mail: list@mpi-muelheim.mpg.de;
Received 20 October 2006

Abstract

Different aldehydes and amines react with acyl cyanides in the presence of a catalytic amount of the Schreiner thiourea catalyst to give the corresponding N-acyl amino nitriles in high yields. The scope of the reaction is broad and both aromatic and aliphatic aldehydes and amines can readily be used.

Key words

acylcyanation - α-amino nitriles - multicomponent reactions - organocatalysis - acyl cyanides