LETTER	Synlett 2007: 0223-0226   DOI: 10.1055/s-2007-968018
© Georg Thieme Verlag Stuttgart · New York
A Novel and Efficient Lewis Acid Catalysed Preparation of Pyrimidines: Microwave-Promoted Reaction of Urea and β-Formyl Enamides
Madan G. Barthakur, Moyurima Borthakur, Prarthana Devi, Chandan J. Saikia, Anil Saikia, Utpal Bora, Apurba Chetia, Romesh C. Boruah*
Medicinal Chemistry Division, Regional Research Laboratory, Jorhat 785006, India Fax: +91(376)2370011; e-Mail: rc_boruah@yahoo.co.in;
Received 16 October 2006

Abstract

A novel and efficient synthesis of pyrimidine from β-formyl enamide is described. The key step involves samarium ­chloride catalysed cyclisation of β-formyl enamides using urea as source of ammonia under microwave irradiation.

Key words

β-formyl enamide - urea - microwave - pyrimidine