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| LETTER | Synlett 2007: 0395-0398
DOI: 10.1055/s-2007-968032 |
© Georg Thieme Verlag Stuttgart · New York
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Octanol-Accelerated Baylis-Hillman Reaction
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| Kwang-Su Parka, Jinyoung Kima, Hyunah Choo*b, Youhoon Chong*a |
a Department of Bioscience and Biotechnology, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Korea
Fax: +82(2)4548217; e-Mail: chongy@konkuk.ac.kr;
b Life Sciences Division, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea
e-Mail: hchoo@kist.re.kr;
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Received
23 October 2006 |
Abstract
The Baylis-Hillman reaction was greatly accelerated by use of octanol as an additive. Under the octanol-accelerated Baylis-Hillman conditions, unactivated aldehydes such as aliphatic aldehydes and aromatic aldehydes with electron-withdrawing substituents were readily converted into the desired products in good to high yields. Key words
Baylis-Hillman reaction - octanol - additive - rate acceleration - aliphatic aldehydes
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