LETTER	Synlett 2007: 0881-0884   DOI: 10.1055/s-2007-973862
© Georg Thieme Verlag Stuttgart · New York
General, Mild and Efficient Synthesis of β-Enaminones Catalyzed by Ceric Ammonium Nitrate
Vellaisamy Sridharan, Carmen Avendaño, J. Carlos Menéndez*
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain Fax: +34(91)3941822; e-Mail: josecm@farm.ucm.es;
Received 9 January 2007

Abstract

Ceric ammonium nitrate catalyzes the reaction between aromatic or aliphatic primary amines and a variety of β-dicarbonyl compounds, including β-ketoesters, β-ketothioesters and β-diketones. The reaction proceeds smoothly at room temperature in short reaction times and gives β-enaminones in good to excellent yields.

Key words

enaminones - ceric ammonium nitrate - lanthanides - Lewis acids - β-dicarbonyl compounds