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| LETTER | Synlett 2007: 1083-1084
DOI: 10.1055/s-2007-977420 |
© Georg Thieme Verlag Stuttgart · New York
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Stereocontrolled Synthesis of (S)-γ-Fluoroleucine
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| Dharshana Padmakshana, Simon A. Bennetta, Gottfried Otting*a, Christopher J. Easton*a,b |
a Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia
Fax: +61(2)61258114; e-Mail: easton@rsc.anu.edu.au;
b ARC Centre of Excellence in Free Radical Chemistry and Biotechnology
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Received
26 June 2006 |
Abstract
Starting with (S)-leucine, the corresponding γ-fluoride 8 has been prepared in a stereocontrolled fashion, by exploiting methods for the direct side-chain bromination of amino acid derivatives and silver(I) fluoride as the fluorinating reagent. Key words
(S)-γ-fluoroleucine - stereoselective synthesis - silver fluoride - amino acids - halogenation
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