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| LETTER | Synlett 2007: 1317-1319
DOI: 10.1055/s-2007-980338 |
© Georg Thieme Verlag Stuttgart · New York
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An Efficient New Procedure for the One-Pot Conversion of Aldehydes into the Corresponding Nitriles
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| Jia-Liang Zhu*a, Fa-Yen Leea, Jen-Dar Wub, Chun-Wei Kuob, Kak-Shan Shia*b |
a Department of Chemistry, National Dong-Hwa University, Hualien 974, Taiwan, R.O.C.
Fax: +886(38)633570; e-Mail: jlzhu@mail.ndhu.edu.tw;
b Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 350, Taiwan, R.O.C.
Fax: +886(37)586456; e-Mail: ksshia@nhri.org.tw;
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Received
30 January 2007 |
Abstract
A new and efficient procedure for the one-pot conversion of various aldehydes into the corresponding nitriles under mild reaction conditions has been developed. The ethyl dichlorophosphate/DBU-mediated dehydration of aldoxime intermediates was utilized as a key operation to effect the transformation. Key words
aldehydes - nitriles - ethyl dichlorophosphate - DBU - dehydration
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