LETTER	Synlett 2007: 1383-1386   DOI: 10.1055/s-2007-980344
© Georg Thieme Verlag Stuttgart · New York
Highly Stereoselective Cobalt-Catalyzed Allylation of Functionalized Diarylzinc Reagents
Guillaume Dunet, Paul Knochel*
Department Chemie und Biochemie, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377 München, Germany Fax: +49(89)218077680; e-Mail: Paul.Knochel@cup.uni-muenchen.de;
Received 27 February 2007

Abstract

Functionalized diarylzinc reagents react readily with ­allylic chlorides or phosphates in the presence of Co(acac)₂ (10 mol%) to give the S_N2 products in high yields and with retention of the double-bond configuration. Functionalities like ester, ketone, or cyano are tolerated.

Key words

catalysis - allylation - cobalt catalysis - organozinc reagents - stereoselective cross-coupling - nocarasin C