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| LETTER | Synlett 2007: 1545-1548
DOI: 10.1055/s-2007-982536 |
© Georg Thieme Verlag Stuttgart · New York
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A Catalytic Method for the Reduction of Secondary and Tertiary Phosphine Oxides
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| Mikaël Berthoda, Alain Favre-Réguillona,b, Jahjah Mohamada, Gérard Mignanic, Gordon Dochertyd, Marc Lemaire*a |
a Laboratoire de Catalyse et Synthèse Organique, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), CNRS, UMR5246, Université Lyon 1, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France
Fax: +33(4)72448507; e-Mail: marc.lemaire@univ-lyon1.fr;
b Laboratoire de Chimie Organique, UMR 7084, Conservatoire National des Arts et Métiers, 2 Rue Conté, 75003 Paris, France
c Rhodia, Lyon Research Center, 85, Avenue des Frères Perret, BP 62, 69192 Saint-Fons Cedex, France
d Rhodia, Novacare, P.O. Box 80, Trinity Street, Oldbury, B69 4LN, UK
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Received
26 March 2007 |
Abstract
TMDS has been found to be an efficient hydride source for the reduction of tertiary and secondary phosphine oxides using a catalytic amount of Ti(Oi-Pr)4. All classes of tertiary phosphine oxides, such as triaryl, trialkyl, and diphosphine, were effectively reduced. Key words
phosphorus - reductions - titanium - hydrosiloxane - phosphine oxides
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