 |
| PAPER | Synthesis 2008: 2191-2198
DOI: 10.1055/s-2008-1067154 |
© Georg Thieme Verlag
Stuttgart ˙ New York
|
 |
Facile Access to 2-Arylindolines
and 2-Arylindoles by Microwave-Assisted Tandem Radical Cyclization
|
| Inga Prediger, Torsten Weiss, Oliver Reiser* |
Institute of Organic Chemistry, University of Regensburg, Universitätsstr.
31, 93053 Regensburg, Germany
Fax: +49(941)9434121; e-Mail: Oliver.Reiser@chemie.uni-regensburg.de;
|
|
Received
21 April 2008 |
Abstract
A new route providing access to 2-arylindoles has been developed.
The synthesis consists of a tin-mediated tandem radical cyclization
of appropriate precursors to form 2,3-disubstituted dihydroindoles,
which in turn are oxidized to yield the corresponding 2-arylindoles.
The reactions proceed smoothly under microwave irradiation, furnishing
the desired products in good yields. Key words
indoles - cyclizations - heterocycles - radical
reactions - dehydrogenations - microwave irradiation
| |
