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Klin Monbl Augenheilkd 2009; 226(10): 829-838
DOI: 10.1055/s-0028-1109529
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Kataraktextraktion und Blaulicht – Wirkung auf die Netzhaut

Cataract Extraction and Blue Light – Impact on the RetinaK. Engelmann1 , R. H. Funk2, 3
  • 1Augenklinik, Klinikum Chemnitz gGmbH
  • 2Anatomie, TU Dresden
  • 3DFG-Center for Regenerative Therapies Dresden
Further Information

Publication History

Eingegangen: 31.3.2009

Angenommen: 25.5.2009

Publication Date:
14 July 2009 (online)

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Zusammenfassung

Dieser Artikel soll die Hintergründe der inzwischen häufigen Verwendung von „gelben Kunstlinsen” beleuchten – insbesondere die paradoxe Situation, dass zahlreiche grundlagenwissenschaftliche Untersuchungen unmissverständlich auf einen Sinn dieser Maßnahme hinweisen, es jedoch bei klinischen epidemiologischen Studien schwerer fällt, hier eindeutige Wirkbeziehungen herzustellen. So soll zunächst gezeigt werden, dass Anteile des sichtbaren Lichtes, insbesondere die kurzwelligen Anteile (vor allem das Blaulicht), für die Netzhaut des Auges und Sehnervs und damit für das Sehen in einem vielfältigen Sinne schädlich sein können. Aus der inzwischen ungeheuer stark angewachsenen Literatur zu „Blaulichtschaden” und oxidativem Stress der Retina, insbesondere der Makula, sollen die Hauptquellen für Radikalentstehung nach Lichteinwirkung herausgefiltert werden. Darüber hinaus soll von den nun vorliegenden zahlreichen Zell- und molekularbiologischen Studien, von den Tierversuchen und von den ersten klinischen Befunden abgeleitet werden, dass es sich aus Vor- und Fürsorge gerade für ältere und AMD-Patienten empfiehlt, nach kataraktbedingter Entfernung der Linse getönte Kunstlinsen einzusetzen.

Abstract

This review focuses on the scientific background for the use of ”yellow artificial lenses”. We will address the fact that numerous basic scientific publications point to a rationale for this practice although it is often difficult to derive clear-cut evidence from clinical epidemiological studies for the preventive use of yellow artificial lenses. In the first part we refer to studies showing that especially the shortwave part of the visible spectrum of light can be harmful for the retina and optic nerve. For this, we have screened the literature for the major sources of radical production and for the targets of oxidative stress after impingement of ”blue light” on the retina. Furthermore, we can show that many studies in cell and molecular biology, animal experiments and first clinical trials point to a preferential use of yellow-tinted lenses especially in the elderly and AMD patients.

Schlüsselwörter

Katarakt - refraktive Chirurgie - Retina - Blaulicht - gelbe Linse

Key words

cataract - refractive Surgery - retina - blue light - yellow lens

Literatur

  • 1 Barker F, Brainard G. The direct spectral transmittance of excised human lens as a function of age.  US Food and Drug Administration Report. 1991;  FDA 7853 450090 RA
    Google Scholar
  • 2 Boettner E A, Wolter J R. Transmission of the ocular media.  Invest Ophthalmol. 1962;  1 776-783
    Google Scholar
  • 3 Bron A J, Vrensen G F, Koretz J. et al . The ageing lens.  Ophthalmologica. 2000;  214 86-104
    Google Scholar
  • 4 Norren van D, Kraats van de J. Spectral transmission of intraocular lenses expressed as a virtual age.  Br J Ophthalmol. 2007;  91 1374-1375
    Google Scholar
  • 5 Algvere P V, Seregard S. Age-related maculopathy: pathogenetic features and new treatment modalities.  Acta Ophthalmol Scand. 2002;  80 136-143
    Google Scholar
  • 6 Wu J, Seregard S, Algvere P V. Photochemical damage of the retina.  Surv Ophthalmol. 2006;  51 461-481
    Google Scholar
  • 7 Grimm C, Wenzel A, Hafezi F. et al . Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration.  Nat Genet. 2000;  25 63-66
    Google Scholar
  • 8 Grimm C, Reme C E, Rol P O. et al . Blue light’s effects on rhodopsin: photoreversal of bleaching in living rat eyes.  Invest Ophthalmol Vis Sci. 2000;  41 3984-3990
    Google Scholar
  • 9 Grimm C, Wenzel A, Williams T. et al . Rhodopsin-mediated blue-light damage to the rat retina: effect of photoreversal of bleaching.  Invest Ophthalmol Vis Sci. 2001;  42 497-505
    Google Scholar
  • 10 Organisciak D T, Jiang Y L, Wang H M. et al . The protective effect of ascorbic acid in retinal light damage of rats exposed to intermittent light.  Invest Ophthalmol Vis Sci. 1990;  31 1195-1202
    Google Scholar
  • 11 Wu J, Chen E, Soderberg P G. Failure of ascorbate to protect against broadband blue light-induced retinal damage in rat.  Graefes Arch Clin Exp Ophthalmol. 1999;  237 855-860
    Google Scholar
  • 12 Delmelle M. Retinal sensitized photodynamic damage to liposomes.  Photochem Photobiol. 1978;  28 357-360
    Google Scholar
  • 13 Rozanowska M, Wessels J, Boulton M. et al . Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar media.  Free Radic Biol Med. 1998;  24 1107-1112
    Google Scholar
  • 14 Foote C S. Mechanisms of photosensitized oxidation. There are several different types of photosensitized oxidation which may be important in biological systems.  Science. 1968;  162 963-970
    Google Scholar
  • 15 Witting L A. Lipid peroxidation in vivo.  J Am Oil Chem Soc. 1965;  42 908-913
    Google Scholar
  • 16 Spikes J D, Macknight M L. Photodynamic effects on molecules of biological importance: amino acids, peptides and proteins.  Res Prog Org Biol Med Chem. 1972;  3 (Pt 1) 124-136
    Google Scholar
  • 17 Sperling H G, Harwerth R S. Red-green cone interactions in the increment-threshold spectral sensitivity of primates.  Science. 1971;  172 180-184
    Google Scholar
  • 18 Sperling H G, Johnson C, Harwerth R S. Differential spectral photic damage to primate cones.  Vision Res. 1980;  20 1117-1125
    Google Scholar
  • 19 Katz M L, Christianson J S, Gao C L. et al . Iron-induced fluorescence in the retina: dependence on vitamin A.  Invest Ophthalmol Vis Sci. 1994;  35 3613-3624
    Google Scholar
  • 20 Katz M L, Gao C L. Vitamin A incorporation into lipofuscin-like inclusions in the retinal pigment epithelium.  Mech Ageing Dev. 1995;  84 29-38
    Google Scholar
  • 21 Katz M L, Gao C L, Rice L M. Formation of lipofuscin-like fluorophores by reaction of retinal with photoreceptor outer segments and liposomes.  Mech Ageing Dev. 1996;  92 159-174
    Google Scholar
  • 22 Wassell J, Boulton M. A role for vitamin A in the formation of ocular lipofuscin.  Br J Ophthalmol. 1997;  81 911-918
    Google Scholar
  • 23 Birch D G, Berson E L, Sandberg M A. Diurnal rhythm in the human rod ERG.  Invest Ophthalmol Vis Sci. 1984;  25 236-238
    Google Scholar
  • 24 Young R W. Shedding of discs from rod outer segments in the rhesus monkey.  J Ultrastruct Res. 1971;  34 190-203
    Google Scholar
  • 25 Marshall J. The ageing retina: physiology or pathology.  Eye. 1987;  1 (Pt 2) 282-295
    Google Scholar
  • 26 Acharya S, Foletta V C, Lee J W. et al . SPACRCAN, a novel human interphotoreceptor matrix hyaluronan-binding proteoglycan synthesized by photoreceptors and pinealocytes.  J Biol Chem. 2000;  275 6945-6955
    Google Scholar
  • 27 Hollyfield J G. Hyaluronan and the functional organization of the interphotoreceptor matrix.  Invest Ophthalmol Vis Sci. 1999;  40 2767-2769
    Google Scholar
  • 28 Hollyfield J G, Rayborn M E, Nishiyama K. et al . Interphotoreceptor matrix in the fovea and peripheral retina of the primate Macaca mulatta: distribution and glycoforms of SPACR and SPACRCAN.  Exp Eye Res. 2001;  72 49-61
    Google Scholar
  • 29 Funk R H. Blood supply of the retina.  Ophthalmic Res. 1997;  29 320-325
    Google Scholar
  • 30 Alder V A, Ben-Nun J, Cringle S J. PO2 profiles and oxygen consumption in cat retina with an occluded retinal circulation.  Invest Ophthalmol Vis Sci. 1990;  31 1029-1034
    Google Scholar
  • 31 Linsenmeier R A, Braun R D, McRipley M A. et al . Retinal hypoxia in long-term diabetic cats.  Invest Ophthalmol Vis Sci. 1998;  39 1647-1657
    Google Scholar
  • 32 Jang Y C, Remmen H V. The mitochondrial theory of aging: Insight from transgenic and knockout mouse models.  Exp Gerontol. 2009;  44 (4) 256-260
    Google Scholar
  • 33 Lascaratos G, Ji D, Wood J P. et al . Visible light affects mitochondrial function and induces neuronal death in retinal cell cultures.  Vision Res. 2007;  47 1191-1201
    Google Scholar
  • 34 Yang J H, Basinger S F, Gross R L. et al . Blue light-induced generation of reactive oxygen species in photoreceptor ellipsoids requires mitochondrial electron transport.  Invest Ophthalmol Vis Sci. 2003;  44 1312-1319
    Google Scholar
  • 35 Osborne N N, Li G Y, Ji D. et al . Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies.  J Neurochem. 2008;  105 2013-2028
    Google Scholar
  • 36 Osborne N N, Lascaratos G, Bron A J. et al . A hypothesis to suggest that light is a risk factor in glaucoma and the mitochondrial optic neuropathies.  Br J Ophthalmol. 2006;  90 237-241
    Google Scholar
  • 37 Noell W K. Aspects of experimental and hereditary degeneration. C Graymore Biochemistry of the retina London; Academic Press 1965: 51-72
    Google Scholar
  • 38 Noell W K, Walker V S, Kang B S. et al . Retinal damage by light in rats.  Invest Ophthalmol. 1966;  5 450-473
    Google Scholar
  • 39 Wenzel A, Grimm C, Samardzija M. et al . Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration.  Prog Retin Eye Res. 2005;  24 275-306
    Google Scholar
  • 40 Wiegand R D, Giusto N M, Rapp L M. et al . Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina.  Invest Ophthalmol Vis Sci. 1983;  24 1433-1435
    Google Scholar
  • 41 Tanito M, Yoshida Y, Kaidzu S. et al . Detection of lipid peroxidation in light-exposed mouse retina assessed by oxidative stress markers, total hydroxyoctadecadienoic acid and 8-iso-prostaglandin F 2alpha.  Neurosci Lett. 2006;  398 63-68
    Google Scholar
  • 42 Kuwabara T, Gom R A. Retina damage by visible light. An electron microscopic study.  Arch Ophthalmol. 1968;  79 69-78
    Google Scholar
  • 43 O’Steen W K, Shear C R, Anderson K V. Retinal damage after prolonged exposure to visible light. A light and electron microscopic study.  Am J Anat. 1972;  134 5-21
    Google Scholar
  • 44 Sykes S M, Robison W G, Waxler Jr M. et al . Damage to the monkey retina by broad-spectrum fluorescent light.  Invest Ophthalmol Vis Sci. 1981;  20 425-434
    Google Scholar
  • 45 Ham W T, Ruffolo Jr J J, Mueller H A. et al . Histologic analysis of photochemical lesions produced in rhesus retina by short-wave-length light.  Invest Ophthalmol Vis Sci. 1978;  17 1029-1035
    Google Scholar
  • 46 Bok Jr D. The retinal pigment epithelium: a versatile partner in vision.  J Cell Sci Suppl. 1993;  17 189-195
    Google Scholar
  • 47 Bok D. Processing and transport of retinoids by the retinal pigment epithelium.  Eye. 1990;  4 (Pt 2) 326-332
    Google Scholar
  • 48 Saari J C, Bredberg D L, Noy N. Control of substrate flow at a branch in the visual cycle.  Biochemistry. 1994;  33 3106-3112
    Google Scholar
  • 49 Boulton M, Dontsov A, Jarvis-Evans J. et al . Lipofuscin is a photoinducible free radical generator.  J Photochem Photobiol B. 1993;  19 201-204
    Google Scholar
  • 50 Davies S, Elliott M H, Floor E. et al . Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells.  Free Radic Biol Med. 2001;  31 256-265
    Google Scholar
  • 51 Holz F G, Pauleikhoff D, Klein R. et al . Pathogenesis of lesions in late age-related macular disease.  Am J Ophthalmol. 2004;  137 504-510
    Google Scholar
  • 52 Wihlmark U, Wrigstad A, Roberg K. et al . Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation.  Free Radic Biol Med. 1997;  22 1229-1234
    Google Scholar
  • 53 Avalle L B, Wang Z, Dillon J P. et al . Observation of A 2E oxidation products in human retinal lipofuscin.  Exp Eye Res. 2004;  78 895-898
    Google Scholar
  • 54 Cubeddu R, Taroni P, Hu D N. et al . Photophysical studies of A 2-E, putative precursor of lipofuscin, in human retinal pigment epithelial cells.  Photochem Photobiol. 1999;  70 172-175
    Google Scholar
  • 55 Liu J, Itagaki Y, Ben-Shabat S. et al . The biosynthesis of A 2E, a fluorophore of aging retina, involves the formation of the precursor, A 2-PE, in the photoreceptor outer segment membrane.  J Biol Chem. 2000;  275 29354-29360
    Google Scholar
  • 56 Mata N L, Weng J, Travis G H. Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration.  Proc Natl Acad Sci U S A. 2000;  97 7154-7159
    Google Scholar
  • 57 Parish C A, Hashimoto M, Nakanishi K. et al . Isolation and one-step preparation of A 2E and iso-A2E, fluorophores from human retinal pigment epithelium.  Proc Natl Acad Sci U S A. 1998;  95 14 609-14 613
    Google Scholar
  • 58 Weng J, Mata N L, Azarian S M. et al . Insights into the function of Rim protein in photoreceptors and etiology of Stargardt’s disease from the phenotype in abcr knockout mice.  Cell. 1999;  98 13-23
    Google Scholar
  • 59 Rezai K A, Gasyna E, Seagle B L. et al . AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium.  Graefes Arch Clin Exp Ophthalmol. 2008;  246 671-676
    Google Scholar
  • 60 Schutt F, Davies S, Kopitz J. et al . Photodamage to human RPE cells by A 2-E, a retinoid component of lipofuscin.  Invest Ophthalmol Vis Sci. 2000;  41 2303-2308
    Google Scholar
  • 61 Sparrow J R, Nakanishi K, Parish C A. The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.  Invest Ophthalmol Vis Sci. 2000;  41 1981-1989
    Google Scholar
  • 62 Boulton M, Rozanowska M, Rozanowski B. Retinal photodamage.  J Photochem Photobiol B. 2001;  64 144-161
    Google Scholar
  • 63 Sparrow J R, Cai B. Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2.  Invest Ophthalmol Vis Sci. 2001;  42 1356-1362
    Google Scholar
  • 64 Gaillard E R, Atherton S J, Eldred G. et al . Photophysical studies on human retinal lipofuscin.  Photochem Photobiol. 1995;  61 448-453
    Google Scholar
  • 65 Sparrow J R, Miller A S, Zhou J. Blue light-absorbing intraocular lens and retinal pigment epithelium protection in vitro.  J Cataract Refract Surg. 2004;  30 873-878
    Google Scholar
  • 66 Tanito M, Elliott M H, Kotake Y. et al . Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina.  Invest Ophthalmol Vis Sci. 2005;  46 3859-3868
    Google Scholar
  • 67 Ranchon I, LaVail M M, Kotake Y. et al . Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P 23 H and S 334ter rhodopsin transgenic rats from inherited retinal degeneration.  J Neurosci. 2003;  23 6050-6057
    Google Scholar
  • 68 Shen J, Yang X, Dong A. et al . Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa.  J Cell Physiol. 2005;  203 457-464
    Google Scholar
  • 69 Crabb J W, Miyagi M, Gu X. et al . Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.  Proc Natl Acad Sci U S A. 2002;  99 14682-14687
    Google Scholar
  • 70 Gu X, Meer S G, Miyagi M. et al . Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration.  J Biol Chem. 2003;  278 42 027-42 035
    Google Scholar
  • 71 Dunaief J L, Dentchev T, Ying G S. et al . The role of apoptosis in age-related macular degeneration.  Arch Ophthalmol. 2002;  120 1435-1442
    Google Scholar
  • 72 Glenn J V, Mahaffy H, Wu K. et al . Advanced glycation end product (AGE) accumulation on Bruch’s membrane: links to age-related RPE dysfunction.  Invest Ophthalmol Vis Sci. 2009;  50 441-451
    Google Scholar
  • 73 Howes K A, Liu Y, Dunaief J L. et al . Receptor for advanced glycation end products and age-related macular degeneration.  Invest Ophthalmol Vis Sci. 2004;  45 3713-3720
    Google Scholar
  • 74 Schmidt K G, Bergert H, Funk R HW. Neurodegenerative Diseases of the Retina and Potential for Protection and Recovery.  Current Neuropharmacology. 2008;  6 164-178
    Google Scholar
  • 75 Wu J, Seregard S, Spangberg B. et al . Blue light induced apoptosis in rat retina.  Eye. 1999;  13 (Pt 4) 577-583
    Google Scholar
  • 76 Shaban H, Richter C. A2E and blue light in the retina: the paradigm of age-related macular degeneration.  Biol Chem. 2002;  383 537-545
    Google Scholar
  • 77 Ham W T, Mueller H A, Ruffolo Jr J J. et al . Sensitivity of the retina to radiation damage as a function of wavelength.  Photochem Photobiol. 1979;  29 735-743
    Google Scholar
  • 78 Ham Jr W T, Mueller H A, Sliney D H. Retinal sensitivity to damage from short wavelength light.  Nature. 1976;  260 153-155
    Google Scholar
  • 79 Lawwill Jr T, Crockett S, Currier G. Retinal damage secondary to chronic light exposure, thresholds and mechanisms.  Doc Ophthalmol. 1977;  44 379-402
    Google Scholar
  • 80 Ts’o M O, Fine B S, Zimmerman L E. Photic maculopathy produced by the indirect ophthalmoscope. 1. Clinical and histopathologic study.  Am J Ophthalmol. 1972;  73 686-699
    Google Scholar
  • 81 Noell W K. Effects of environmental lighting and dietary vitamin A on the vulnerability of the retina to light damage.  Photochem Photobiol. 1979;  29 717-723
    Google Scholar
  • 82 Battelle B A, LaVail M M. Rhodopsin content and rod outer segment length in albino rat eyes: modification by dark adaptation.  Exp Eye Res. 1978;  26 487-497
    Google Scholar
  • 83 Organisciak D T, Noell W K. The rod outer segment phospholipid/opsin ratio of rats maintained in darkness or cyclic light.  Invest Ophthalmol Vis Sci. 1977;  16 188-190
    Google Scholar
  • 84 Organisciak D T, Wang H M, Li Z Y. et al . The protective effect of ascorbate in retinal light damage of rats.  Invest Ophthalmol Vis Sci. 1985;  26 1580-1588
    Google Scholar
  • 85 Penn J S, Anderson R E. Effect of light history on rod outer-segment membrane composition in the rat.  Exp Eye Res. 1987;  44 767-778
    Google Scholar
  • 86 Penn J S, Naash M I, Anderson R E. Effect of light history on retinal antioxidants and light damage susceptibility in the rat.  Exp Eye Res. 1987;  44 779-788
    Google Scholar
  • 87 Liang H L, Whelan H T, Eells J T. et al . Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity.  Neuroscience. 2008;  153 963-974
    Google Scholar
  • 88 Klein R, Klein B E, Linton K L. Prevalence of age-related maculopathy. The Beaver Dam Eye Study.  Ophthalmology. 1992;  99 933-943
    Google Scholar
  • 89 Mainster M A, Ham W T, Delori F C. Potential retinal hazards. Instrument and environmental light sources.  Ophthalmology. 1983;  90 927-932
    Google Scholar
  • 90 Margrain T H, Boulton Jr M, Marshall J. et al . Do blue light filters confer protection against age-related macular degeneration?.  Prog Retin Eye Res. 2004;  23 523-531
    Google Scholar
  • 91 Schrader W F. Age-related macular degeneration: a socioeconomic time bomb in our aging society.  Ophthalmologe. 2006;  103 742-748
    Google Scholar
  • 92 Scholl H P, Fleckenstein M, Charbel Issa P. et al . An update on the genetics of age-related macular degeneration.  Mol Vis. 2007;  13 196-205
    Google Scholar
  • 93 Swaroop A, Branham K E, Chen W. et al . Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.  Hum Mol Genet. 2007;  16 (Spec No. 2) R174-R182
    Google Scholar
  • 94 Gu J, Paeur G J, Yue X. et al . Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers.  Mol Cell Proteomics. 2009;  8 (6) 1338-1349
    Google Scholar
  • 95 Barron M J, Johnson M A, Andrews R M. et al . Mitochondrial abnormalities in ageing macular photoreceptors.  Invest Ophthalmol Vis Sci. 2001;  42 3016-3022
    Google Scholar
  • 96 Nilsson S E, Textorius O, Andersson B E. et al . Clear PMMA versus yellow intraocular lens material. An electrophysiologic study on pigmented rabbits regarding ”the blue light hazard”.  Prog Clin Biol Res. 1989;  314 539-553
    Google Scholar
  • 97 Tanito M, Kaidzu S, Anderson R E. Protective effects of soft acrylic yellow filter against blue light-induced retinal damage in rats.  Exp Eye Res. 2006;  83 1493-1504
    Google Scholar
  • 98 Sperduto R D, Hiller R, Seigel D. Lens opacities and senile maculopathy.  Arch Ophthalmol. 1981;  99 1004-1008
    Google Scholar
  • 99 West S K, Rosenthal F S, Bressler N M. et al . Exposure to sunlight and other risk factors for age-related macular degeneration.  Arch Ophthalmol. 1989;  107 875-879
    Google Scholar
  • 100 Mitchell P, Smith W, Attebo K. et al . Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study.  Ophthalmology. 1995;  102 1450-1460
    Google Scholar
  • 101 Mitchell P, Wang J J, Foran S. et al . Five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye Study.  Ophthalmology. 2002;  109 1092-1097
    Google Scholar
  • 102 VanNewkirk M R, Nanjan M B, Wang J J. et al . The prevalence of age-related maculopathy: the visual impairment project.  Ophthalmology. 2000;  107 1593-1600
    Google Scholar
  • 103 Wang J J, Klein R, Smith W. et al . Cataract surgery and the 5-year incidence of late-stage age-related maculopathy: pooled findings from the Beaver Dam and Blue Mountains eye studies.  Ophthalmology. 2003;  110 1960-1967
    Google Scholar
  • 104 Wang J J, Mitchell P G, Cumming R G. et al . Cataract and age-related maculopathy: the Blue Mountains Eye Study.  Ophthalmic Epidemiol. 1999;  6 317-326
    Google Scholar
  • 105 Werner J S, Steele V G, Pfoff D S. Loss of human photoreceptor sensitivity associated with chronic exposure to ultraviolet radiation.  Ophthalmology. 1989;  96 1552-1558
    Google Scholar
  • 106 Schaft T L, Mooy C M, Bruijn de W C. et al . Increased prevalence of disciform macular degeneration after cataract extraction with implantation of an intraocular lens.  Br J Ophthalmol. 1994;  78 441-445
    Google Scholar
  • 107 Pollack van der A, Marcovich A, Bukelman A. et al . Age-related macular degeneration after extracapsular cataract extraction with intraocular lens implantation.  Ophthalmology. 1996;  103 1546-1554
    Google Scholar
  • 108 Armbrecht A M, Findlay C, Aspinall P A. et al . Cataract surgery in patients with age-related macular degeneration: one-year outcomes.  J Cataract Refract Surg. 2003;  29 686-693
    Google Scholar
  • 109 Kaiserman I, Kaiserman N, Elhayany A. et al . Cataract surgery is associated with a higher rate of photodynamic therapy for age-related macular degeneration.  Ophthalmology. 2007;  114 278-282
    Google Scholar
  • 110 Baatz H, Darawsha R, Ackermann H. et al . Phacoemulsification does not induce neovascular age-related macular degeneration.  Invest Ophthalmol Vis Sci. 2008;  49 1079-1083
    Google Scholar
  • 111 Cugati S, Mitchell P, Rochtchina E. et al . Cataract surgery and the 10-year incidence of age-related maculopathy: the Blue Mountains Eye Study.  Ophthalmology. 2006;  113 2020-2025
    Google Scholar
  • 112 Cugati S, Loryn de T, Pham T. et al . Australian prospective study of cataract surgery and age-related macular degeneration: rationale and methodology.  Ophthalmic Epidemiol. 2007;  14 408-414
    Google Scholar
  • 113 Armbrecht A M, Findlay C, Kaushal S. et al . Is cataract surgery justified in patients with age related macular degeneration? A visual function and quality of life assessment.  Br J Ophthalmol. 2000;  84 1343-1348
    Google Scholar
  • 114 Shuttleworth G N, Galloway P H. Analysis of the United Kingdom solar eclipse public health campaign 1999.  Clin Experiment Ophthalmol. 2002;  30 308-310
    Google Scholar
  • 115 Shuttleworth G N, Luhishi E A, Harrad R A. Do patients with age related maculopathy and cataract benefit from cataract surgery?.  Br J Ophthalmol. 1998;  82 611-616
    Google Scholar
  • 116 Falkner-Radler C I, Benesch T, Binder S. Blue light-filter intraocular lenses in vitrectomy combined with cataract surgery: results of a randomized controlled clinical trial.  Am J Ophthalmol. 2008;  145 499-503
    Google Scholar
  • 117 Takahashi H. Free radical development in phacoemulsification cataract surgery.  J Nippon Med Sch. 2005;  72 4-12
    Google Scholar
  • 118 Riesz P, Kondo T. Free radical formation induced by ultrasound and its biological implications.  Free Radic Biol Med. 1992;  13 247-270
    Google Scholar
  • 119 Shimmura S, Tsubota K, Oguchi Y. et al . Oxiradical-dependent photoemission induced by a phacoemulsification probe.  Invest Ophthalmol Vis Sci. 1992;  33 2904-2907
    Google Scholar
  • 120 Nemet A Y, Assia E I, Meyerstein D. et al . Protective effect of free-radical scavengers on corneal endothelial damage in phacoemulsification.  J Cataract Refract Surg. 2007;  33 310-315
    Google Scholar
  • 121 Rubowitz A, Assia E I, Rosner M. et al . Antioxidant protection against corneal damage by free radicals during phacoemulsification.  Invest Ophthalmol Vis Sci. 2003;  44 1866-1870
    Google Scholar
  • 122 De Biaggi C P, Barros P SM, Silva V V. et al . Ascorbic acid levels of aqueous humor of dogs after experimental phacoemulsification.  Veterinary Ophthalmology. 2006;  9 299-302
    Google Scholar
  • 123 Cameron M D, Poyer J F, Aust S D. Identification of free radicals produced during phacoemulsification.  J Cataract Refract Surg. 2001;  27 463-470
    Google Scholar
  • 124 Dherani M, Murthy G V, Gupta S K. et al . Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population.  Invest Ophthalmol Vis Sci. 2008;  49 3328-3335
    Google Scholar
  • 125 Yagihashi T, Wakabayashi Y, Kezuka J. et al . Changes in vitreous amino acid concentrations in a rabbit model of cataract surgery.  Acta Ophthalmol Scand. 2007;  85 303-308
    Google Scholar

Prof. Katrin Engelmann

Klinik für Augenheilkunde, Klinikum Chemnitz gGmbH

Flemmingstr. 2

09116 Chemnitz

Phone: ++ 49/3 71/33 33 32 30

Fax: ++ 49/3 71/33 33 32 23

Email: k.engelmann@skc.de

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