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Exp Clin Endocrinol Diabetes 1988; 91(3): 247-258
DOI: 10.1055/s-0029-1210755
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Teratogenetic Maternofoetal Transmission and Prevention of Diabetes Susceptibility-1)

G. Dörner, A. Plagemann, J. Rückert, F. Götz, W. Rohde, F. Stahl, U. Kürschner, J. Gottschalk1 , A. Mohnike2 , E. Steindel2
  • Institute of Experimental Endocrinology, Berlin/GDR
  • 1Institute of Pathology, Berlin/GDR
  • 2Humboldt University Medical School (Charité) and Diabetes Centre, Berlin/GDR
1) Presented at the XVIII Annual Meeting of the Diabetes and Pregnancy Study Group of the European Association for the Study of Diabetes, Berlin/GDR, September 13-15, 1987
Further Information

Publication History

1987

Publication Date:
16 July 2009 (online)

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Summary

Gestational diabetes and impaired glucose tolerance in pregnancy were found to be important teratogenetic risk factors for the development of diabetes in the offspring. Mechanisms of action and prevention of maternofetal transmission of teratogenetic susceptibility to diabetes are presented. Gestational diabetes induced in the F0 generation produced the following effects in the F1 and/or F2 generation: Early postnatal hyperinsulinaemia, decreased noradrenaline and serotonin and increased endorphin concentrations in specific brain regions, permanent hypoplasia of the hypothalamic ventromedial nuclei, decreased insulin responsiveness to glucose, impaired glucose tolerance and increased diabetes susceptibility.

Key words

Diabetes mellitus - Teratogenetic susceptibility - Maternofoetal transmission - Prevention

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