A Simple Large-Scale Synthesis
of Cbz-Protected Taurylsulfonyl Azide

Arwin J. Brouwer; Rob M. J. Liskamp

doi:10.1055/s-0030-1261201

LETTER

A Simple Large-Scale Synthesis of Cbz-Protected Taurylsulfonyl Azide

Arwin J. Brouwer, Rob M. J. Liskamp*
Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
Fax: +31(30)2536655; e-Mail: R.M.J.Liskamp@uu.nl;

Abstract

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Abstract

A simple and efficient method for the large-scale synthesis of Cbz-taurylsulfonyl azide is described. This sulfonyl azide is accessible from taurine using three or four synthetic steps.

Key words

sulfonyl azide - sulfonyl chloride - large-scale synthesis - chemoselectivity - sulfo-click reaction

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References

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