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Thromb Haemost 2002; 87(01): 37-41
DOI: 10.1055/s-0037-1612940
Review Article
Schattauer GmbH

The Effect of Fibrinogen Genotype on Fibrinogen Levels after Strenuous Physical Exercise

D.J. Brull
1   Division of Cardiovascular Genetics, Department of Medicine, Royal Free and UCL Medical School
,
S. Dhamrait
1   Division of Cardiovascular Genetics, Department of Medicine, Royal Free and UCL Medical School
,
R. Moulding
1   Division of Cardiovascular Genetics, Department of Medicine, Royal Free and UCL Medical School
,
A. Rumley
2   Department of Medicine, University of Glasgow
,
G. D. O. Lowe
2   Department of Medicine, University of Glasgow
,
M. J. World
3   Royal Defence Medical College, Fort Blockhouse, Gosport, Hampshire, UK
,
S. E. Humphries
1   Division of Cardiovascular Genetics, Department of Medicine, Royal Free and UCL Medical School
,
H. E. Montgomery
1   Division of Cardiovascular Genetics, Department of Medicine, Royal Free and UCL Medical School
› Author Affiliations
Further Information

Publication History

Received 12 June 2001

Accepted after resubmission 01 October 2001

Publication Date:
14 December 2017 (online)

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Summary

We have examined the effect of two f3-fibrinogen gene promoter polymorphisms (-455G>A and -854G>A) on the fibrinogen response to severe exercise in a group of male army recruits undergoing basic training. Fibrinogen was measured pre-training and again serially after severe 48 h final military exercise (FME). Out of 884 subjects, 762 completed training of whom 250 were selected for post-FME study. Fibrinogen levels (g/l) were significantly elevated over baseline levels 2, 48 and 96 h after FME, representing increases of 15.7%, 3.4% and 7.6% (p <0.005; p = 0.05 and p <0.005 respectively), with higher levels in -455A allele carriers than genotype -455GG: 3.17 ± 0.05 vs. 2.94 ± 0.05 (p <0.001), 2.86 ± 0.05 vs. 2.60 ± 0.05 (p <0.0005) and 2.98 ± 0.06 vs. 2.69 ± 0.06 (p <0.0005) at 2, 48 and 96 h respectively. There was no effect of the -854G>A polymorphism on fibrinogen, even after taking into account f3-fibrinogen -455 genotype. Thus the fibrinogen -455G>A polymorphism influences fibrinogen levels following exercise. The effect of genotype might be clinically relevant at times of hyperfibrinogenaemia such as following an acute inflammatory response.

Keywords

Fibrinogen - genetics - exercise
 

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