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Thromb Haemost 2002; 88(01): 26-31
DOI: 10.1055/s-0037-1613148
Review Article
Schattauer GmbH

Association of γA/γ’ Fibrinogen Levels and Coronary Artery Disease

Rehana S. Lovely
1   Department of Pathology, Oregon Health & Science University, Portland, OR
,
Lisa A. Falls
3   Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
,
Hamid A. Al-Mondhiry
4   Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, PA
,
Charles E. Chambers
4   Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, PA
,
Gary J. Sexton
2   Clinical Research Center, Oregon Health & Science University, Portland, OR
,
Hanyu Ni
5   Division of Health Interview Statistics, National Center for Health Statistics, Hyattsville, MD, USA
,
David H. Farrell
1   Department of Pathology, Oregon Health & Science University, Portland, OR
› Author Affiliations
Further Information

Publication History

Received 27 December 2001

Accepted 27 February 2002

Publication Date:
09 December 2017 (online)

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Summary

γA/γ’ fibrinogen is a fibrinogen isoform that constitutes about 15% of total plasma fibrinogen. This isoform contains an additional binding site for zymogen factor XIII and for active thrombin, and forms fibrin clots that are resistant to fibrinolysis in vitro. Little is known about the variability of γA/γ’ fibrinogen levels in human populations, whereas total fibrinogen levels are known to increase with age and are higher in women than in men. In this report, evidence is presented that, in contrast to total fibrinogen levels, γA/γ’ fibrinogen levels showed no significant association with age or gender in a population of normal blood donors. A study of γA/γ’ fibrinogen levels in patients undergoing coronary angiography also showed that γA/γ’ fibrinogen levels were higher on average in coronary artery disease patients than in patients without coronary artery disease, and that this association was independent of total fibrinogen levels.

Keywords

Age - coronary - epidemiology - fibrinogen - gender
 

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