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CC BY-NC-ND 4.0 · Journal of Fetal Medicine
DOI: 10.1055/s-0044-1786170
Review Article

Binder Phenotype—Prenatal Diagnosis, Management, and Postnatal Outcome: Insights from a Case Series and Updated Review of the Literature

Brinda Sabu 
1   Department of Maternal-Fetal Medicine, KIMSHEALTH Hospital, Trivandrum, Kerala, India
,
Dhanya Shenoy
1   Department of Maternal-Fetal Medicine, KIMSHEALTH Hospital, Trivandrum, Kerala, India
,
Vidyalekshmy R.
1   Department of Maternal-Fetal Medicine, KIMSHEALTH Hospital, Trivandrum, Kerala, India
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Abstract

Binder phenotype (BP) or maxillonasal dysplasia is a developmental disorder of the anterior part of the maxilla and nasal complex and is characterized by a short nose with a flat nasal bridge, short columella, acute nasolabial angle, perialar flatness, convex upper lip, and tendency to a class III malocclusion. The etiology of BP is heterogeneous with diverse features and outcomes. The ultrasound features of BP are midfacial hypoplasia with verticalized nasal bones, short columella with flattened tip and alar wings, and the nasofrontal angle measuring >140 degrees. In this case series, we present seven cases of BP detected antenatally, their varied etiology, management, and outcomes with a 2-year follow-up. We conclude that the diagnosis of facial dysmorphisms, such as BP, brings a lot of apprehension and agony in the parents amounting to multiple tests and counseling sessions. Physiognomy which is the normal familial appearance should be considered before concluding whether the observed feature is normal or pathological. Accurate diagnosis, adequate testing, and personalized counseling will help in the prevention of needless termination of pregnancies and ensure an optimal perinatal outcome.

Keywords

Binder phenotype - Binder syndrome - maxillonasal hypoplasia - midfacial hypoplasia - nasofrontal angle - facial dysmorphism


Publikationsverlauf

Artikel online veröffentlicht:
16. April 2024

© 2024. Society of Fetal Medicine. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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