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Semin Musculoskelet Radiol 2003; 7(4): 245-248
DOI: 10.1055/s-2004-815674
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Dynamic and Functional Imaging of the Musculoskeletal System

Garry E. Gold
  • Stanford University, Stanford, CA, 94305
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Publication History

Publication Date:
21 January 2004 (online)

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ABSTRACT

Conventional magnetic resonance imaging (MRI) examination of the musculoskeletal system is limited to static evaluation of muscle, spine, and joint morphology. However, using the variety of contrast mechanisms available with MRI, it is possible to obtain functional and biomechanical data about the musculoskeletal system. The function of joints and muscles are for motion and weight bearing, so pathology that only occurs during activity can be missed on static MRI examination. Similarly, important information about muscle biomechanics, muscle energetics, and joint function can be obtained with unique MRI contrast such as T 2-mapping, spectroscopy, blood-oxygenation-level-dependent (BOLD) imaging, and molecular imaging. These new techniques hold the promise for a more complete and useful joint examination.

KEYWORDS

MRI - functional - T2-mapping - dynamic - kinematic

REFERENCES

  • 1 Witonski D. Dynamic magnetic resonance imaging.  Clin Sports Med . 2002;  21 403-415
    CrossrefPubMedGoogle Scholar
  • 2 Shellock F G, Feske W, Frey C, Terk M. Peroneal tendons: use of kinematic MR imaging of the ankle to determine subluxation.  J Magn Reson Imaging . 1997;  7 451-454
    CrossrefPubMedGoogle Scholar
  • 3 Beaulieu C F, Hodge D K, Bergman A G. et al . Glenohumeral relationships during physiologic shoulder motion and stress testing: initial experience with open MR imaging and active imaging-plane registration.  Radiology . 1999;  212 699-705
    PubMedGoogle Scholar
  • 4 Shellock F G, Stone K R, Crues J V. Development and clinical application of kinematic MRI of the patellofemoral joint using an extremity MR system.  Med Sci Sports Exerc . 1999;  31 788-791
    PubMedGoogle Scholar
  • 5 Weishaupt D, Treiber K, Jacob H A. et al . MR imaging of the forefoot under weight-bearing conditions: position-related changes of the neurovascular bundles and the metatarsal heads in asymptomatic volunteers.  J Magn Reson Imaging . 2002;  16 75-84
    CrossrefPubMedGoogle Scholar
  • 6 Kerr A B, Pauly J M, Hu B S. et al . Real-time interactive MRI on a conventional scanner.  Magn Reson Med . 1997;  38 355-367
    PubMedGoogle Scholar
  • 7 Quick H H, Ladd M E, Hoevel M. et al . Real-time MRI of joint movement with trueFISP.  J Magn Reson Imaging . 2002;  15 710-715
    CrossrefPubMedGoogle Scholar
  • 8 Nayak K S, Pauly J M, Kerr A B, Hu B S, Nishimura D G. Real-time color flow MRI.  Magn Reson Med . 2000;  43 251-258
    CrossrefPubMedGoogle Scholar
  • 9 Hodge D K, Beaulieu C F, Thabit III H G. et al . Dynamic MR imaging and stress testing in glenohumeral instability: comparison with normal shoulders and clinical/surgical findings.  J Magn Reson Imaging . 2001;  13 748-756
    CrossrefPubMedGoogle Scholar
  • 10 Weishaupt D, Zanetti M, Hodler J, Boos N. MR imaging of the lumbar spine: prevalence of intervertebral disk extrusion and sequestration, nerve root compression, end plate abnormalities, and osteoarthritis of the facet joints in asymptomatic volunteers.  Radiology . 1998;  209 661-666
    CrossrefPubMedGoogle Scholar
  • 11 Danielson B, Willen J. Axially loaded magnetic resonance image of the lumbar spine in asymptomatic individuals.  Spine . 2001;  26 2601-2606
    CrossrefPubMedGoogle Scholar
  • 12 Zamani A A, Moriarty T, Hsu L. et al . Functional MRI of the lumbar spine in erect position in a superconducting open-configuration MR system: preliminary results.  J Magn Reson Imaging . 1998;  8 1329-1333
    CrossrefPubMedGoogle Scholar
  • 13 Drace J E, Pelc N J. Skeletal muscle contraction: analysis with use of velocity distributions from phase-contrast MR imaging.  Radiology . 1994;  193 423-429
    PubMedGoogle Scholar
  • 14 Asakawa D S, Blemker S S, Gold G E, Delp S L. In vivo motion of the rectus femoris muscle after tendon transfer surgery.  J Biomech . 2002;  35 1029-1037
    CrossrefPubMedGoogle Scholar
  • 15 Pappas G P, Asakawa D S, Delp S L, Zajac F E, Drace J E. Nonuniform shortening in the biceps brachii during elbow flexion.  J Appl Physiol . 2002;  92 2381-2389
    PubMedGoogle Scholar
  • 16 Sheehan F T, Drace J E. Human patellar tendon strain. A noninvasive, in vivo study.  Clin Orthop . 2000;  370 201-207
    PubMedGoogle Scholar
  • 17 Sheehan F T, Zajac F E, Drace J E. In vivo tracking of the human patella using cine phase contrast magnetic resonance imaging.  J Biomech Eng . 1999;  121 650-656
    PubMedGoogle Scholar
  • 18 Kent-Braun J A, Ng A V, Castro M. et al . Strength, skeletal muscle composition, and enzyme activity in multiple sclerosis.  J Appl Physiol . 1997;  83 1998-2004
    PubMedGoogle Scholar
  • 19 Kent-Braun J A, McCully K K, Chance B. Metabolic effects of training in humans: a 31P-MRS study.  J Appl Physiol . 1990;  69 1165-1170
    PubMedGoogle Scholar
  • 20 Fleckenstein J L, Canby R C, Parkey R W, Peshock R M. Acute effects of exercise on MR imaging of skeletal muscle in normal volunteers.  AJR Am J Roentgenol . 1988;  151 231-237
    PubMedGoogle Scholar
  • 21 Fisher M J, Meyer R A, Adams G R, Foley J M, Potchen E J. Direct relationship between proton T2 and exercise intensity in skeletal muscle MR images.  Invest Radiol . 1990;  25 480-485
    CrossrefPubMedGoogle Scholar
  • 22 Adams G R, Duvoisin M R, Dudley G A. Magnetic resonance imaging and electromyography as indexes of muscle function.  J Appl Physiol . 1992;  73 1578-1583
    PubMedGoogle Scholar
  • 23 Yue G, Alexander A L, Laidlaw D H, Gmitro A F, Unger E C, Enoka R M. Sensitivity of muscle proton spin-spin relaxation time as an index of muscle activation.  J Appl Physiol . 1994;  77 84-92
    PubMedGoogle Scholar
  • 24 Ploutz L L, Tesch P A, Biro R L, Dudley G A. Effect of resistance training on muscle use during exercise.  J Appl Physiol . 1994;  76 1675-1681
    CrossrefPubMedGoogle Scholar
  • 25 Akima H, Takahashi H, Kuno S-Y. et al . Early phase adaptations of muscle use and strength to isokinetic training.  Med Sci Sports Exerc . 1999;  31 588-594
    CrossrefPubMedGoogle Scholar
  • 26 Meyer R A, Prior B M. Functional magnetic resonance imaging of muscle.  Exerc Sport Sci Rev . 2000;  28 89-92
    PubMedGoogle Scholar
  • 27 Fleckenstein J L. MRI of neuromuscular disease: the basics.  Semin Musculoskelet Radiol . 2000;  4 393-419
    Article in Thieme ConnectPubMedGoogle Scholar
  • 28 Boesch C, Kreis R. Observation of intramyocellular lipids by 1H-magnetic resonance spectroscopy.  Ann N Y Acad Sci . 2000;  904 25-31
    CrossrefPubMedGoogle Scholar
  • 29 Kuhlmann J, Neumann-Haefelin C, Belz U. et al . Intramyocellular lipid and insulin resistance: a longitudinal in vivo 1H-spectroscopic study in Zucker diabetic fatty rats.  Diabetes . 2003;  52 138-144
    PubMedGoogle Scholar
  • 30 Sprott H, Rzanny R, Reichenbach J R, Kaiser W A, Hein G, Stein G. 31P magnetic resonance spectroscopy in fibromyalgic muscle.  Rheumatology (Oxford) . 2000;  39 1121-1125
    CrossrefPubMedGoogle Scholar
  • 31 Shellock F G, Fleckenstein J L. Muscle physiology and pathophysiology: magnetic resonance imaging evaluation.  Semin Musculoskelet Radiol . 2000;  4 459-479
    Article in Thieme ConnectPubMedGoogle Scholar
  • 32 Gold G E, Pauly J M, Macovski A, Herfkens R J. MR spectroscopic imaging of collagen: tendons and knee menisci.  Magn Reson Med . 1995;  34 647-654
    PubMedGoogle Scholar
  • 33 Donahue K M, Van Kylen J, Guven S. et al . Simultaneous gradient-echo/spin-echo EPI of graded ischemia in human skeletal muscle.  J Magn Reson Imaging . 1998;  8 1106-1113
    CrossrefPubMedGoogle Scholar
  • 34 McCully K K, Posner J D. The application of blood flow measurements to the study of aging muscle.  J Gerontol A Biol Sci Med Sci . 1995;  50(Special Issue) 130-136
    PubMedGoogle Scholar
  • 35 Li X, Gu W, Masinde G. et al . Genetic variation in bone-regenerative capacity among inbred strains of mice.  Bone . 2001;  29 134-140
    CrossrefPubMedGoogle Scholar
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