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Der Nuklearmediziner 2004; 27(3): 196-200
DOI: 10.1055/s-2004-822723
Kardiologie aktuell

© Georg Thieme Verlag Stuttgart · New York

Bildgebung der kardialen Innervation: Wann gelingt der Sprung in die Klinik?

Imaging of Cardiac Innervation: When will it Reach Clinical Value?M. Schäfers1 , 2 , O. Schober1
  • 1Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Münster
  • 2Institut für Arterioskleroseforschung, Westfälische Wilhelms-Universität, Münster
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Publication History

Publication Date:
16 September 2004 (online)

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Zusammenfassung

Die autonome Nervenversorgung des Herzens ist an der Regulation einer Vielzahl grundlegender Funktionen des Herzens und der Gefäße (Perfusion, Rhythmus, Metabolismus, Kontraktion etc.) beteiligt. Dies lässt eine Involvierung des autonomen Nervensystems im Rahmen pathophysiologischer Vorgänge am Herzen erwarten, die klinisch u. a. auch in der medikamentösen Therapie des autonomen Nervensystems (z. B. β-Blocker) Ausdruck findet. Eine nicht-invasive bildgebende Diagnostik der autonomen Innervation des Herzens sollte daher in Diagnostik, Therapieentscheidung und -kontrolle sowie in der Prognoseabschätzung klinische Bedeutung erlangen. Szintigraphische Verfahren sind einzigartig in der Lage, die kardiale autonome Innervation (sympathisch und parasympathisch) nicht-invasiv bildgebend darzustellen und zu quantifizieren. Obwohl geeignete Technologien bereits vorhanden sind, sind diese innovativen Bildgebungsansätze noch nicht in klinische Algorithmen integriert.

Abstract

The autonomic nervous system is involved in the regulation of the majority of basic cardiac and vascular functions, e. g. the control of perfusion, rhythm, metabolism and contraction. This results in an involvement of the autonomic nervous system in many pathophysiologic processes affecting the heart. Furthermore, in clinical medicine the autonomic nervous system is a target of specific pharmacological treatment such as β-blockade. Imaging of the autonomic nervous system in a clinical context should therefore proof useful in clinical decision making and therapy control of cardiovascular diseases. Today, scintigraphic techniques are a unique mean to image and quantify sympathetic and parasympathetic cardiac innervation non-invasively in vivo. Although these technologies are already available, these are not yet implemented in clinical algorithms.

Schlüsselwörter

Autonomes Nervensystem - sympathische Intervention - MIBG - Arrhythmie - Kardiomyopathie

Key words

Autonomic nervous system - sympathetic innervation - MIBG - arrhythmia - cardiomyopathy

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Univ.-Prof. Dr. med. Michael Schäfers

Klinik und Poliklinik für Nuklearmedizin · Universitätsklinikum Münster

Albert-Schweitzer-Str. 33

48129 Münster

Phone: 02 51-8 34 73 62

Fax: 02 51-8 34 73 63

Email: schafmi@uni-muenster.de

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