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Horm Metab Res 1993; 25(8): 407-410
DOI: 10.1055/s-2007-1002133
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© Georg Thieme Verlag, Stuttgart · New York

Effects of Thyroxine Supplement on Serum Insulin-Like Growth Factor-Binding Activity in Propylthiouracil Induced Hypothyroid Cockerels

D. Morishita, M. Wakita, S. Hoshino
  • Faculty of Bioresources, Mie University, Tsu, Japan
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Publikationsverlauf

1992

1993

Publikationsdatum:
14. März 2008 (online)

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Summary

In propylthiouracil (PTU)-fed (g/kg feed) hypothyroid cockerels, serum levels of growth hormone (GH), but not insulin-like growth factor (IGF)-1, tended to rise and those of IGF-binding activity to fall. Thyroxine (T4) supplement (200 μg/kg/day) to PTU-fed cockerels for 8 days produced a hyperthyroid state and reversed these serum parameters. A chromatographic analysis of serum proteins revealed that T4 supplement markedly enhanced the IGF-binding activity of a 30 kDa protein and slightly lowered that of a 150 kDa protein, suggesting that T4 increases unsaturated IGF-binding proteins by reducing circulating IGF-1 concentrations.

Key words

Chicken - Hypothyroid - Thyroxine - IGF-Binding Proteins

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