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Horm Metab Res 1986; 18(3): 159-162
DOI: 10.1055/s-2007-1012260
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

The Effects of Porcine GIP on Insulin Secretion and Glucose Clearance in the Pig

K. H. Wolffbrandt, K. Damm Jørgensen, A. J. Moody, P. C. Pedersen
  • Novo Industri A/S, Bagsvaerd, Denmark
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Publikationsverlauf

1984

1985

Publikationsdatum:
14. März 2008 (online)

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Summary

The present study was undertaken with the aims of studying the pharmacological effects and the pharmacokinetics of porcine GIP in pigs in vivo.

Infusion of GIP and glucose resulted in a significant increase in the insulin release compaired to the insulin release after glucose infusion in the control group.

A significant increase in glucose clearance was also seen during GIP infusions.

A two compartment open model with first order kinetics was used for the description of the pharmacokinetics of the infused GIP. The plasma half-life for GIP was found to be between 34-35 minutes.

Key-Words

Porcine GIP - Glucose Clearance - Insulin Secretion - Pig

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