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Horm Metab Res 1986; 18(3): 201-202
DOI: 10.1055/s-2007-1012270
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Single Dose Responses to the Gonadotropin-Releasing Hormone Agonist Analogue [(imBz1)-D-His6,Pro9-NEt]GnRH

G. C. Doelle, R. M. Evans, A. Nancye Alexander, J. Rivier1 , W. Vale1 , D. Rabin
  • Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, U.S.A.
  • 1The Salk Institute, La Jolla, California, U.S.A.
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Publikationsverlauf

1984

1984

Publikationsdatum:
14. März 2008 (online)

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Summary

The agonist analogue of gonadotropin-releasing hormone (GnRH), [(imBz1)-D-His6,Pro9-NEt]GnRH, has a potency 200 times that of the native hormone in vitro. In single dose studies in man, this analogue resulted in 2- to 4-fold elevation of LH and FSH, and demonstrated a prolonged duration of activity. [(imBz1)-D-His6,Pro9-NEt]GnRH appears to be safe and, as with other analogues of GnRH, may have application to clinical medicine.

Key-Words

GnRH Agonist Analogues

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