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Horm Metab Res 1986; 18(5): 327-330
DOI: 10.1055/s-2007-1012307
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Alpha Cell Autoantibodies: Immunological and Metabolic Follow-Up Study

C. Betterle, F. Zanette, F. Presotto, B. Pedini, P. Tessari, A. Valerio, A. Tiengo
  • Institute of Semeiotica Medica, and Department of Gerontology, Padua University Medical School, Padua, Italy
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Publikationsverlauf

1984

1985

Publikationsdatum:
14. März 2008 (online)

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Summary

We studied glucagon responses to OGTT and insulin and arginine stimulation in 12 out of 21 patients who were found positive for alpha cell autoantibodies (ACA) during routine screening procedures for autoimmunity in a group of 4080 individuals. The study was repeated in 8 subjects after an average observation period of 42 months. In both studies glucagon plasma levels were normal and independent of ACA titres, ACA ability to fix complement and ACA ability to cross-react with duodenal alpha cells. The clinical significance of ACA remains to be elucidated.

Key-Words

Organ Specific Autoimmunity - Pancreatic Autoimmunity - Indirect Immunofluorescence - Alpha Cell Autoantibodies - Delta Cell Autoantibodies - Hypoglucagonemia

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