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Horm Metab Res 1986; 18(10): 659-662
DOI: 10.1055/s-2007-1012400
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

Phosphatidylinositol Kinase in Rat Pancreatic Islets: Subcellular Distribution and Sensitivity to Calcium

R. S. Rana, M. J. MacDonald
  • University of Wisconsin Medical School, Madison, Wisconsin, U.S.A.
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Publikationsverlauf

1985

1985

Publikationsdatum:
14. März 2008 (online)

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Summary

Plasma membrane of pancreatic islets contains a calcium sensitive phosphatidylinositol kinase. This enzyme catalyzes the first reaction in the pathway leading to the production of inositol trisphosphate, which is believed to cause a redistribution of intracellular calcium. Since the activity of this enzyme is inhibited by calcium (K0.5 = 10 μM),a loss of calcium from plasma membrane (the site of PI kinase) may be necessary for activation of the enzyme in vivo.

Key-Words

Pancreatic Islets - Rat - Phosphatidylinositol - Phosphatidylinositol Kinase - Calcium Inhibition - Plasma Membrane

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