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Thromb Haemost 2003; 90(06): 986-992
DOI: 10.1160/TH03-06-0399
Theme Issue Article
Schattauer GmbH

Matricellular proteins as modulators of wound healing and the foreign body response

Themis R. Kyriakides
1   Departments of Biochemistry, University of Washington, Seattle, Washington, USA
,
Paul Bornstein
1   Departments of Biochemistry, University of Washington, Seattle, Washington, USA
2   Departments of Medicine, University of Washington, Seattle, Washington, USA
› Author Affiliations
Further Information

Publication History

Received 25 June 2003

Accepted after resubmission 24 September 2003

Publication Date:
05 December 2017 (online)

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Summary

Matricellular proteins form a group of extracellular matrix (ECM) proteins that do not subserve a primary structural role, but rather function as modulators of cell-matrix interactions (1). Members of the group, including thrombospondin (TSP) -1, TSP-2, SPARC, tenascin (TN)-C, and osteopontin (OPN), have been shown to participate in a number of processes related to tissue repair. Specifically, studies in knockout mice have indicated that a deficiency in one or more of these proteins can alter the course of wound healing. More recently, TSP1, TSP2, and SPARC have also been implicated in the foreign body response, an unusual reaction to injury that occurs after the implantation of biomaterials. This review will focus on the roles of these proteins in the response to injury in mice and will show how studies of this pathophysiological process can elucidate some of the intrinsic properties of these matricellular proteins.

Keywords

Matricellular proteins - wound healing - foreign body response - thrombospondin - cell-matrix interactions
 

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