Thromb Haemost 2013; 109(04): 625-632
DOI: 10.1160/TH12-08-0568
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Characteristics of abdominal vein thrombosis in children and adults

Daniel Landi
1   Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
,
Michele G. Beckman
2   Centers for Disease Control and Prevention, Atlanta, Georgia, USA
,
Nirmish R. Shah
1   Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
3   Division of Hematology, Duke University Medical Center, Durham, North Carolina, USA
,
Paula Bockenstedt
4   Hematology Oncology, University of Michigan, Ann Arbor, Michigan, USA
,
Althea M. Grant
2   Centers for Disease Control and Prevention, Atlanta, Georgia, USA
,
John A. Heit
5   Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
,
Nigel S. Key
8   University of North Carolina, Chapel Hill, North Carolina, USA
,
Roshni Kulkarni
6   Pediatrics & Human Dev., Michigan State University, East Lansing, Michigan, USA
,
Marilyn Manco-Johnson
7   University of Colorado and Children’s Hospital, Aurora, Colorado, USA
,
Stephan Moll
8   University of North Carolina, Chapel Hill, North Carolina, USA
,
Claire S. Philipp
9   University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
,
Judith C. Andersen
10   Wayne State University, Karmanos Cancer Institute, Detroit, Michigan, USA
,
Thomas L. Ortel
3   Division of Hematology, Duke University Medical Center, Durham, North Carolina, USA
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 10. August 2012

Accepted after major revision: 11. Januar 2013

Publikationsdatum:
22. November 2017 (online)

Summary

The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the setting of known disease might have prognostic implications different from LE DVT/PE. This study describes clinical presentations of abdominal VT compared to LE DVT/PE in adults and children. We analysed prospec-tively-collected data from consecutive consenting patients enrolled in one of seven Centers for Disease Control and Prevention (CDC) funded Thrombosis and Hemostasis Network Centers from August 2003 to April 2011 to compare the demographic and clinical characteristics of adults and children with abdominal VT. Both adults and children with abdominal VT tended to be younger and have a lower body mass index (BMI) than those with LE DVT/PE. Of patients with abdominal V T, children were more likely to have inferior vena cava (IVC) thrombosis than adults. For adults with venous thromboembolism (VTE), relatively more women had abdominal VT than LE DVT/PE, while the proportions with LE DVT/PE and abdominal VT by sex were similar in children. Children with abdominal VT were more likely to have diagnosed inherited thrombophilia, while trauma was more common in children with LE DVT/PE. In conclusion, both children and adults with abdominal VT were younger with a lower BMI than those with LE DVT/ PE. Significant differences exist between children and adults in respect to abdominal VT compared to LE DVT/PE.

Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

 
  • References

  • 1 Raffini L, Huang YS, Witmer C. et al. Dramatic increase in venous thromboembolism in children’s hospitals in the United States from 2001 to 2007. Paediatrics 2009; 124: 1001-1008.
  • 2 Chan AK, Deveber G, Monagle P. et al. Venous thrombosis in children. J Thromb Haemost 2003; 01: 1443-1455.
  • 3 Goldenberg NA. Long-term outcomes of venous thrombosis in children. Curr Opin Hematol 2005; 12: 370-376.
  • 4 Journeycake JM, Manco-Johnson MJ. Thrombosis during infancy and childhood: what we know and what we do not know. Hematol Oncol Clin North Am 2004; 18: 1315-1338. viii-ix.
  • 5 Silverstein MD, Heit JA, Mohr DN. et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 1998; 158: 585-593.
  • 6 Gangat N, Wolanskyj AP, Tefferi A. Abdominal vein thrombosis in essential thrombocythemia: prevalence, clinical correlates, and prognostic implications. Eur J Haematol 2006; 77: 327-333.
  • 7 Goldenberg NA, Bernard TJ. Venous thromboembolism in children. Hematol Oncol Clin North Am 2010; 24: 151-166.
  • 8 Monagle P, Adams M, Mahoney M. et al. Outcome of paediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia Registry. Paediatr Res 2000; 47: 763-766.
  • 9 Schmidt B, Andrew M. Neonatal thrombosis: report of a prospective Canadian and international registry. Paediatrics 1995; 96: 939-943.
  • 10 Dowling NF, Beckman MG, Manco-Johnson M, The US. et al. Thrombosis and Haemostasis Centres pilot sites program. J Thromb Thrombolysis 2007; 23: 1-7.
  • 11 Miyakis S, Lockshin MD, Atsumi T. et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 04: 295-306.
  • 12 Stein PD, Kayali F, Olson RE. Incidence of venous thromboembolism in infants and children: data from the National Hospital Discharge Survey. J Paediatr 2004; 145: 563-565.
  • 13 Tormene D, Simioni P, Prandoni P. et al. The incidence of venous thromboembolism in thrombophilic children: a prospective cohort study. Blood 2002; 100: 2403-2405.
  • 14 Young G, Albisetti M, Bonduel M. et al. Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies. Circulation 2008; 118: 1373-1382.
  • 15 Babyn PS, Gahunia HK, Massicotte P. Pulmonary thromboembolism in children. Paediatr Radiol 2005; 35: 258-274.
  • 16 Massicotte P, Julian JA, Gent M. et al. An open-label randomized controlled trial of low molecular weight heparin for the prevention of central venous line-related thrombotic complications in children: the PROTEKT trial. Thromb Res 2003; 109: 101-108.
  • 17 Kosch A, Kuwertz-Broking E, Heller C. et al. Renal venous thrombosis in neon-ates: prothrombotic risk factors and long-term follow-up. Blood 2004; 104: 1356-1360.
  • 18 Prandoni P, Lensing AW, Cogo A. et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 1996; 125: 1-7.
  • 19 Nowak-Gottl U, Junker R, Kreuz W. et al. Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors. Blood 2001; 97: 858-862.
  • 20 Massicotte MP, Dix D, Monagle P. et al. Central venous catheter related thrombosis in children: analysis of the Canadian Registry of Venous Thromboembolic Complications. J Paediatr 1998; 133: 770-776.
  • 21 Sharathkumar AA, Pipe SW. Post-thrombotic syndrome in children: a single centre experience. J Paediatr Hematol Oncol 2008; 30: 261-266.
  • 22 Segal JB, Streiff MB, Hofmann LV. et al. Management of venous thromboembol-ism: a systematic review for a practice guideline. Ann Intern Med 2007; 146: 211-222.