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Vet Comp Orthop Traumatol 2009; 22(02): 96-102
DOI: 10.3415/VCOT-08-04-0038
Original Research
Schattauer GmbH

Comparison of two β-tricalcium phosphate composite grafts used for reconstruction of mandibular critical size bone defects

M. C. Nolff
1   Department of Oral and Maxillofacial Surgery, Hanover Medical School, Hanover, Germany
2   Small Animal Clinic, University of Veterinary Medicine Hanover, Germany
,
N.-C. Gellrich
1   Department of Oral and Maxillofacial Surgery, Hanover Medical School, Hanover, Germany
,
G. Hauschild
2   Small Animal Clinic, University of Veterinary Medicine Hanover, Germany
3   Department of Orthopedics, University of Muenster, Muenster, Germany
,
M. Fehr
2   Small Animal Clinic, University of Veterinary Medicine Hanover, Germany
,
K.-H. Bormann
1   Department of Oral and Maxillofacial Surgery, Hanover Medical School, Hanover, Germany
,
K. Rohn
4   Department of Biometry, Epidemiology and Information Processing; University of Veterinary Medicine Hanover, Hanover, Germany
,
S. Spalthoff
1   Department of Oral and Maxillofacial Surgery, Hanover Medical School, Hanover, Germany
,
M. Rücker
1   Department of Oral and Maxillofacial Surgery, Hanover Medical School, Hanover, Germany
,
H. Kokemüller
1   Department of Oral and Maxillofacial Surgery, Hanover Medical School, Hanover, Germany
› Author Affiliations
Further Information

Publication History

Received 20 April 2008

Accepted 24 March 2008

Publication Date:
17 December 2017 (online)

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Summary

Objective: The aim was to compare osseointegration of blood perfused β-tricalcium phosphate cylinders (β-TCPB) with similar composites that were additionally loaded with cancellous bone and bone marrow (β-TCPB/BM/CB) for mandibular reconstruction.

Methods: Twelve German Black-Headed sheep with an average weight of 72.5 ± 10 kg underwent segmental re-section of the right hemi-mandible. The animals that were assigned to group A (n=6) were reconstructed using β-TCPB while the sheep that were assigned to group B received β-TCPB/BM/CB grafts. Tissue quality was histologically assessed and bone-, scaffold-, cartilage- and fibrous-tissue area were estimated using semiautomated histomorphometrical software.

Results: Composite grafts that were loaded with bone marrow and cancellous bone (β-TCPB/BM/CB) exhibited significant (p<0.01) higher amounts of bone formation than β-TCPB. The patients that were assigned to group B achieved defect union and a high grade of bone maturation. Residual ceramic remnants were rare and disconnected. Bone maturity within group A was inferior and none of the specimens showed defect union. The defect centre was still occupied by a ceramic core.

Clinical significance: Bone and bone marrow augmented β-tricalcium phosphate composites may qualify as a promising alternative to autograft bone for mandibular reconstruction in human and veterinary medicine.

Keywords

Mandibular continuity resection - β-tricalcium phosphate composite - bone marrow - bone graft substitute - sheep
 

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