Hamostaseologie 2019; 39(S 01): S1-S92
DOI: 10.1055/s-0039-1680152
SY19 Venous Thrombosis, APA-Syndrome
Georg Thieme Verlag KG Stuttgart · New York

Role of Gender and ABO-blood Group in White Adolescents and Young Adult Patients with First VTE Onset

V. Limperger
1   UKSH Kiel & Lübeck, Gerinnungszentrum, Kiel, Germany
2   Medilys Laborgesellschaft, c/o AK Altona, Hamburg, Germany
,
A. Franke
3   CAU Kiel, Institut für klinische Molekularbiologie, Kiel, Germany
,
D. Kowalski
1   UKSH Kiel & Lübeck, Gerinnungszentrum, Kiel, Germany
,
M. Stoll
4   WWU Münster, Institut für Humangenetik, Abt. für Gen. Epidemiologie, Münster, Germany
,
U. Nowak-Göttl
1   UKSH Kiel & Lübeck, Gerinnungszentrum, Kiel, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
13 February 2019 (online)

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    Background: In white patients venous thromboembolism (VTE) is a multifactorial disease. Concomitant with provoking clinical risk factors in > 70% of cases genetic polymorphisms, for example the factor (F5) polymorphism at rs6025, the prothrombin (PT) variants at rs1799963 and rs3136516 are known as additional risk factors. The aim of this analysis was to evaluate the additive role of gender and ABO blood group (BG: 0 versus non-0) in a case-control design.

    Methods: In the present case-control study we analyzed clinical and laboratory data of 1012 Caucasian patients with a first VTE onset aged 14 to 55 years derived from the north-eastern part of Germany. Patients were compared with healthy individuals (blood donors) from the same catchment area and both cohorts were investigated for the presence of gender and ABO-BG. Odds ratios and 95% confidence intervals (OR/CI) were calculated adjusted for F5 at rs6025, the PT variants at rs1799963 and rs3136516 and age.

    Results: In the present multivariable analysis the increased risk of male gender compared with females was 2,35 (1.86–2.97). In addition, compared with BG “0” BG “non-0” was significantly more often found in patients with VTE onset (OR 2,74; CI 2,11–3,55). The adjusted OR of F5 carriers compared with healthy controls was 5,68 (CI 3,94–8,20), 2,38 (1,38–4,20) in patients with PT (rs1799963) mutation, 1,48 (CI:1,06–2,06) for PT (rs3136516: GG genotype) and 1,45 (CI: 1,1–1,92) for carriers of the rs3136516 AG variant.

    Conclusions: In multivariate analysis male gender and BG non-0 were independently associated with an increased risk of VTE in white adolescents and young adults.


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    No conflict of interest has been declared by the author(s).