Klin Padiatr 2020; 232(02): 110
DOI: 10.1055/s-0040-1701936
16 May 2020
S-IX
Session IX: Staging Evaluation and Response Criteria Harmonization (SEARCH) for CAYAHL
© Georg Thieme Verlag KG Stuttgart · New York

The impact of the Point-spread-function (PSF) reconstruction on the response assessment in the Interim-PET (iPET) in Hodgkin lymphoma (HL)

TW Georgi
1   Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
,
L Kurch
1   Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
,
D Hasenclever
2   Statistics and Epidemiology, University of Leipzig, Institute for Medical Informatics, Leipzig, Germany
,
D Körholz
3   Department of Pediatric Oncology, Justus-Liebig-University Gießen, Gießen, Germany
,
O Sabri
1   Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
,
R Kluge
1   Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
,
C Mauz-Körholz
3   Department of Pediatric Oncology, Justus-Liebig-University Gießen, Gießen, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2020 (online)

Also available at
 
 

    Introduction Within the EuroNet-PHL-C2 study the iPET result has an impact on the further treatment. The iPET assessment is done quantitatively by the qPET method (mean SUV of the hottest connected voxel inside the tumor divided by mean SUV of the liver). A qPET-value < 1.30 corresponds to a Deauville score ≤ 3 and implies omission of radiotherapy (RTx). The aim of this study was to investigate the impact of the PSF reconstruction on the further treatment decision in comparison to a pure Ordered-subset-expectation-maximization reconstruction without PSF (OSEM) (current standard).

    Methods The iPET datasets from 106 EuroNet-PHL-C2 patients were investigated. All datasets were available as PSF- as well as pure OSEM-reconstructions. The qPET-values were measured in both reconstruction forms. Based on these results, the influence of PSF concerning the treatment decision (RTx yes/no) was investigated.

    Results 98/106 HL patients showed tumor residuals in iPET. The PSF-qPET-values were 13.3% (± 17.1%) higher than the OSEM-values. These results would have induced a change of treatment in 16/106 patients. The main reason seemed to be the Time-of-Flight (TOF) reconstruction which was applied more often with PSF (84x) than with OSEM (18x). If OSEM and PSF were both reconstructed with or without TOF, the PSF-qPET-values were 4.1% (± 13.7%) higher and a change of treatment would have occurred in 2/36 patients. If only PSF was reconstructed with TOF, the PSF-qPET-values were 19.3% (± 15.9%) higher and the treatment would have changed in 13/61 patients.

    Conclusion The PSF-qPET-values in iPET were higher than the OSEM-qPET-values, especially if PSF was reconstructed with TOF and OSEM without. In these cases, PSF would have induced a radiotherapy in addionally 21% of the patients.


    #

    Conflict of Interest:

    Nothing to declare