Population-Based Database Survival Analyses of Intracranial Meningiomas

Study Design: National database analysis.

Introduction: Intracranial Meningiomas are the most common primary intracranial tumors. There are several treatment options available (observation, radiotherapy, surgery, and combination of surgery and radiotherapy) with different outcomes. Patient and tumor related factors affect the choice of treatment method as well as patient's survival. Here we present a population-based database survival analysis of patients with intracranial meningioma.

Methods: We surveyed the National Cancer Database (NCDB) for the years 2004–2015 to identify patients with a diagnosis of intracranial meningioma using the International Classification of Disease 9 code. We then performed survival analyses of the retrieved data.

Results: A total of 199,096 patients with a diagnosis of intracranial meningioma met the inclusion criteria, 73.3% were females, and 76.4% were white. Mean age was 61 years, and mean Karnofsky score was 74.5. 73.4% of patients had no comorbidities. Patients treated at community hospitals had increased mortality in comparison to academic institutions for all treatment modalities. Increasing age and the presence of comorbidities were associated with increased mortality. Female gender was associated with increased survival. Tumors size >3 cm, and high tumor WHO grade was associated with increased mortality.

Conclusion: There is a multitude of factors that affect survival of patients with intracranial meningioma. Nonacademic institutions, comorbidities, advanced age, larger tumor size, and higher WHO grade are associated with increased mortality.

No conflict of interest has been declared by the author(s).