Nuklearmedizin 2020; 59(02): 112
DOI: 10.1055/s-0040-1708188
Wissenschaftliche Vorträge
Gehirn: Transmitter, Rezeptoren & Stoffwechsel
© Georg Thieme Verlag KG Stuttgart · New York

Cholinergic network modulation of food cue response in humans

E Schweickert de Palma
1   Universität Leipzig, Integriertes Forschungs- und Behandlungszentrum (IFB) AdipositasErkrankungen, Leipzig
,
M Rullmann
1   Universität Leipzig, Integriertes Forschungs- und Behandlungszentrum (IFB) AdipositasErkrankungen, Leipzig
,
GA Becker
2   Universitätsklinikum Leipzig, Klinik und Poliklinik für Nuklearmedizin, Leipzig
,
J Luthardt
2   Universitätsklinikum Leipzig, Klinik und Poliklinik für Nuklearmedizin, Leipzig
,
T Günnewig
1   Universität Leipzig, Integriertes Forschungs- und Behandlungszentrum (IFB) AdipositasErkrankungen, Leipzig
,
F Zientek
1   Universität Leipzig, Integriertes Forschungs- und Behandlungszentrum (IFB) AdipositasErkrankungen, Leipzig
,
PM Meyer
2   Universitätsklinikum Leipzig, Klinik und Poliklinik für Nuklearmedizin, Leipzig
,
M Patt
2   Universitätsklinikum Leipzig, Klinik und Poliklinik für Nuklearmedizin, Leipzig
,
J Neumann
3   Max-Planck-Institut für Kognitions- und Neurowissenschaften, Abteilung Neurologie, Leipzig
,
O Sabri
2   Universitätsklinikum Leipzig, Klinik und Poliklinik für Nuklearmedizin, Leipzig
,
S Hesse
1   Universität Leipzig, Integriertes Forschungs- und Behandlungszentrum (IFB) AdipositasErkrankungen, Leipzig
› Author Affiliations
Further Information

Publication History

Publication Date:
08 April 2020 (online)

 
 

Ziel/Aim Cholinergic modulation of food intake is assumed as nicotinic acetylcholine receptors (nAChR).1 Specifically, α4β2* nAChR are widely expressed in brain feeding circuits. To assess the effects of visual food stimuli on α4β2* nAChR availability in vivo, we applied simultaneous PET-MRI with α4β2* nAChR-specific (-)-[18F]Flubatine in normal-weight volunteers (NW) under basic (basC) and stimulus conditions (stimC).

Methodik/Methods Fifteen NW (13 females; 28±7 yrs; BMI 22±2 kg/m2) underwent PET-MRI (mMR Siemens) twice under basC and stimC. (-)-[18F]Flubatine was applied as a bolus-infusion protocol (294±8 MBq; 165min) paralleled by T1 MPRAGE for anatomical co-registration and functional EPI sequences during basC or stimC. Total distribution volumes (VT) were estimated as ratio between mean radioactivity in tissue (120-165min) and free parent compound in plasma. During 2nd scan, food pictures of different salient information were shown 120-135min p.i. as part of a task-related fMRI. Eigenvector centrality mapping (ECM) was used to analyze fMRI data.

Ergebnisse/Results No significant differences of VT between basC and stimC (e.g. the nucleus accumbens 10.2±0.9 vs. 10.3±1.1, and the ventral tegmental area 17.4±2.2 vs. 17.6±2.6) were found. ECM data showed the insula as a more prominent network under basC, whereas precuneus and inferior parietal cortex were more prominent during stimC.

Schlussfolgerungen/Conclusions These first in human data provide an insight into cholinergic neuromodulation of food reward circuitries. As there were no significant changes in VT between basC and stimC, cholinergic tone seems not to be influenced by visual food stimuli in NW, while fMRI data proposes a significant difference between basC and stimC in neural networks including the primary taste cortex and the default mode network. Further investigation is necessary to explore a difference to human obesity.


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