Nuklearmedizin 2020; 59(02): 159
DOI: 10.1055/s-0040-1708332
Wissenschaftliche Poster
PET, SPECT & Co. III
© Georg Thieme Verlag KG Stuttgart · New York

Optimization of F-18-fluorocholine PET/CT protocol for the detection of hyperfunctioning parathyroid tissue in patients with hyperparathyroidism

A Ntoumanoglou-Schuiki
1   Medizinische Universität Graz, Klinische Abteilung für Nuklearmedizin, Graz
,
TN Hooshmand
1   Medizinische Universität Graz, Klinische Abteilung für Nuklearmedizin, Graz
,
B Pernthaler
1   Medizinische Universität Graz, Klinische Abteilung für Nuklearmedizin, Graz
,
P Ofner-Kopeinig
2   Medizinische Universität Graz, Institut für Medizinische Informatik, Statistik und Dokumentation, Graz
,
RM Aigner
1   Medizinische Universität Graz, Klinische Abteilung für Nuklearmedizin, Graz
› Author Affiliations
Further Information

Publication History

Publication Date:
08 April 2020 (online)

 
 

    Ziel/Aim Accurate preoperative localization of hyperfunctioning parathyroid tissue in patients with hyperparathyroidism (HPT) is a prerequisite for performing minimally invasive surgery. Recent studies demonstrated the high diagnostic value of F-18-fluorocholine (FCH) PET/CT in the preoperative localization of parathyroid adenomas, though the optimal time of imaging after intravenous application of FCH has yet to be established. The aim of this study was to determine an adequate FCH PET/CT protocol and to explore the relationship between FCH PET/CT and laboratory parameters in patients with HPT.

    Methodik/Methods This retrospective study was conducted in 46 patients with biochemically proven HPT after performing FCH PET/CT for preoperative localization. Following early dynamic cervical acquisition, late acquisition of the neck and mediastinum was performed at 15, 30, 45 and 60 minutes post injection (pi). The SUVmax (standardized uptake value) of the suspected parathyroid lesions was measured. Preoperative laboratory results, including parathyroid hormone, serum calcium, phosphate and vitamin D levels were assessed.

    Ergebnisse/Results In average, the suspected parathyroid lesions had the highest FCH uptake at 45 minutes pi with a SUVmax of 8,23 ±3,07. In 26/46 patients ( ≈ 57%) the suspected hyperfunctioning parathyroid tissue showed the highest FCH uptake at 45 minutes pi, followed by 10/46 ( ≈ 22%) patients who showed the highest parathyroid SUVmax at 15 minutes pi. No significant correlation was observed between laboratory parameters and SUVmax.

    Schlussfolgerungen/Conclusions The preferable scan time for late image acquisition is 45 minutes after FCH administration; the need for an early dynamic acquisition is under investigation. According to our results, the examined preoperative laboratory parameters are not predictive of higher FCH uptake in hyperfunctioning parathyroid tissue.


    #