Liver Resection for Non-colorectal, Non-neuroendocrine Metastases

Question Hepatic resection has become a standardized, well-established surgical procedure with substantially improved survival for patients with colorectal and neuroendocrine liver metastases. However, the value of this procedure in non-colorectal and non-neuroendocrine (NCRNNE) metastases remains unclear. This study aims to analyze patients undergoing liver surgery for NCRNNE metastases.

Methods All patients who underwent liver resection for NCRNNE metastases between 2012 and 2017 were included in our study. The outcome of the patients was analyzed according to the primary tumor, histopathology, type of therapy and demographics.

Results Thirty-one patients (16 males, 15 females), with an average age of 54.4 (20-80) years, underwent liver resection with curative intent during the observation period. The most common primary tumors were pancreatic adeno carcinoma (4), renal cell carcinoma (3), esophageal cancer (3), gastrointestinal stromal tumor (3), melanoma (3) and thyroid cancer (3).

Among them, twelve patients were suffering from synchronous liver metastases (38.7 %). [HH1] Microscopic margin-free resection could be achieved in 90.3 % of the patients.

The overall survival rates for 1 year and 3 years were 61.3 % and 45.2 %, respectively.

Conclusion Liver resection should be considered as a curative procedure for patients with metastatic NCRNNE. Further studies are needed to identify the factors allowing improved survival, especially with additive chemotherapeutic regimen.

Publication History

Article published online:
04 January 2021