Senologie - Zeitschrift für Mammadiagnostik und -therapie 2021; 18(02): e18-e19
DOI: 10.1055/s-0041-1730180
Abstracts
Senologie

Identification of risk factors in implant-based mesh supported breast reconstruction - results of the 2years follow up analysis of the PRO Bra Trial

E Klein
1   Klinikum rechts der Isar, Technische Universität München, Klinik und Poliklinik für Frauenheilkunde, München, Deutschland
,
S Paepke
1   Klinikum rechts der Isar, Technische Universität München, Klinik und Poliklinik für Frauenheilkunde, München, Deutschland
,
A Faridi
2   Uniklinikum Bonn, Bonn, Deutschland
,
C Ankel
3   DRK Kliniken Berlin Westend Brustzentrum, Berlin, Deutschland
,
A Meiré
4   St. Elisabeth Krankenhaus, Köln, Deutschland
,
C Gerber-Schäfer
5   Vivantes Klinikum Berlin, Berlin, Deutschland
,
K Baumann
6   St. Marien Klinikum, Siegen, Deutschland
,
JU Blohmer
7   Charité - Universitätsmedizin Berlin, Berlin, Deutschland
,
C Mau
8   Helios Klinikum Berlin Buch, Berlin, Deutschland
,
E Nolte
9   pfm medical AG, Köln, Deutschland
,
M Thill
10   Agaplesion Markus Krankenhaus, Frankfurt/Main, Deutschland
› Author Affiliations
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    Background Patient characteristics and cancer treatment may increase the risk for postoperative complications in breast reconstruction surgery. It is therefore essential to analyse those risk factors’ contribution to outcome of implant-based reconstruction.

    Methods Primary or secondary implant-based breast reconstruction with support of synthetic non-resorbable titanized TiLOOP® Bra surgical mesh was performed in 269 patients during the prospective, multicentre patient reported outcome (PRO)-BRA study (clinicaltrials.gov, NCT01885572, DRKS, DRKS00005342). Secondary endpoint was the evaluation of postoperative complication rates up to 24 months after breast reconstruction. Univariable and multivariable logistic regression analyses were performed to identify risk factors (e.g. BMI, age, radiotherapy, chemotherapy, implant size) increasing the risk for having complications.

    Results Out of 362 breast reconstructions the following factors were identified in univariable logistic regression to be associated with increased risk for distinct complications: Implant size ≥ 75th percentile (>395 cm3) and BMI ≥ 25 kg/m2 (first event, seroma, wound complications), adjuvant radiotherapy (capsular fibrosis), age ≥ 50 years (seroma), transverse/vertical incision (wound complications), and adjuvant chemotherapy (infection/inflammation). Multivariable logistic regression identified implant size ≥ 75th percentile (>395 cm3), neoadjuvant chemotherapy, and age ≥ 50 years as significant risk factors for the occurrence of the first complication.

    Conclusion These specific identified risk factors must be taken into account in implant based to achieve a complication reduced postoperative outcome.


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    Interessenkonflikt

    Stefan Paepke:Beratungstätigkeit, Reisekosten, Unterstützung wiss. Veranstaltungen Grünenthal Sysmex Endomag, Cambridge KCI/3M pfm medical ag Becton&Dickinson/Bard Neodynamics, Schweden Invitrocue, EuropeGmBH NovusScientific, Schweden Triconmed Roche

    Publication History

    Article published online:
    01 June 2021

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