Clin Colon Rectal Surg 2011; 24(3): 171-176
DOI: 10.1055/s-0031-1286001
© Thieme Medical Publishers

Anorectal Melanoma

Amalia Stefanou1 , Surya P.M. Nalamati1
  • 1Division of Colon and Rectal Surgery, Department of Surgery, Henry Ford Hospital, Detroit, Michigan
Further Information

Publication History

Publication Date:
26 August 2011 (online)

ABSTRACT

Anorectal melanoma is a disease that can be difficult to diagnose because of its unclear presentation. After diagnosis, the main treatment available is surgical resection. Sentinel lymph node mapping has an unclear role in its management. Adjuvant therapy has long been recommended; however, there are no strong data to support its use. Prognostic factors to help gauge survival are also not clear; nevertheless, there is a strong association between stage of disease and histologic perineal invasion. Anorectal melanoma is a very rare disease with a dismal prognosis.

REFERENCES

  • 1 Mason J K, Helwig E B. Ano-rectal melanoma.  Cancer. 1966;  19 (1) 39-50
  • 2 Moore H G, Guillem J G. Anal neoplasms.  Surg Clin North Am. 2002;  82 (6) 1233-1251
  • 3 Singer M, Mutch M G. Anal melanoma.  Clin Colon Rectal Surg. 2006;  19 (2) 78-87
  • 4 Chiu Y S, Unni K K, Beart Jr R W. Malignant melanoma of the anorectum.  Dis Colon Rectum. 1980;  23 (2) 122-124
  • 5 Ishizone S, Koide N, Karasawa F et al.. Surgical treatment for anorectal malignant melanoma: report of five cases and review of 79 Japanese cases.  Int J Colorectal Dis. 2008;  23 (12) 1257-1262
  • 6 Thibault C, Sagar P, Nivatvongs S, Ilstrup D M, Wolff B G. Anorectal melanoma—an incurable disease?.  Dis Colon Rectum. 1997;  40 (6) 661-668
  • 7 Yeh J J, Shia J, Hwu W J et al.. The role of abdominoperineal resection as surgical therapy for anorectal melanoma.  Ann Surg. 2006;  244 (6) 1012-1017
  • 8 Yap L B, Neary P. A comparison of wide local excision with abdominoperineal resection in anorectal melanoma.  Melanoma Res. 2004;  14 (2) 147-150
  • 9 Felz M W, Winburn G B, Kallab A M, Lee J R. Anal melanoma: an aggressive malignancy masquerading as hemorrhoids.  South Med J. 2001;  94 (9) 880-885
  • 10 Stoidis C N, Spyropoulos B G, Misiakos E P, Fountzilas C K, Paraskeva P P, Fotiadis C I. Diffuse anorectal melanoma; review of the current diagnostic and treatment aspects based on a case report.  World J Surg Oncol. 2009;  7 64
  • 11 Podnos Y D, Tsai N C, Smith D, Ellenhorn J D. Factors affecting survival in patients with anal melanoma.  Am Surg. 2006;  72 (10) 917-920
  • 12 Weyandt G H, Eggert A O, Houf M, Raulf F, Bröcker E B, Becker J C. Anorectal melanoma: surgical management guidelines according to tumour thickness.  Br J Cancer. 2003;  89 (11) 2019-2022
  • 13 Brady M S, Kavolius J P, Quan S H. Anorectal melanoma. A 64-year experience at Memorial Sloan-Kettering Cancer Center.  Dis Colon Rectum. 1995;  38 (2) 146-151
  • 14 Ward M W, Romano G, Nicholls R J. The surgical treatment of anorectal malignant melanoma.  Br J Surg. 1986;  73 (1) 68-69
  • 15 Ben-Izhak O, Bar-Chana M, Sussman L et al.. Ki67 antigen and PCNA proliferation markers predict survival in anorectal malignant melanoma.  Histopathology. 2002;  41 (6) 519-525
  • 16 Ben-Izhak O, Levy R, Weill S et al.. Anorectal malignant melanoma. A clinicopathologic study, including immunohistochemistry and DNA flow cytometry.  Cancer. 1997;  79 (1) 18-25
  • 17 Chang A E, Karnell L H, Menck H R. The American College of Surgeons Commission on Cancer and the American Cancer Society . The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade.  Cancer. 1998;  83 (8) 1664-1678
  • 18 NIH Consensus Conference. Diagnosis and treatment of early melanoma.  JAMA. 1992;  268 (10) 1314
  • 19 Cohn-Cedermark G, Rutqvist L E, Andersson R. Long-term results of a randomized study by the Swedish Melanoma Study Group on 2-cm versus 5-cm resection margins for patients with cutaneous melanoma with a tumor thickness of 0.8–2.0 mm.  Cancer. 2000;  89 (7) 1495
  • 20 Ballo M T, Gershenwald J E, Zagars G K et al.. Sphincter-sparing local excision and adjuvant radiation for anal-rectal melanoma.  J Clin Oncol. 2002;  20 (23) 4555-4558
  • 21 Bullard K M, Tuttle T M, Rothenberger D A et al.. Surgical therapy for anorectal melanoma.  J Am Coll Surg. 2003;  196 (2) 206-211
  • 22 Droesch J T, Flum D R, Mann G N. Wide local excision or abdominoperineal resection as the initial treatment for anorectal melanoma?.  Am J Surg. 2005;  189 (4) 446-449
  • 23 Olsha O, Mintz A, Gimon Z et al.. Anal melanoma in the era of sentinel lymph node mapping: a diagnostic and therapeutic challenge.  Tech Coloproctol. 2005;  9 (1) 60-62
  • 24 Sanli Y, Turkmen C, Kurul S, Taş F, Mudun A, Cantez S. Sentinel lymph node biopsy for the staging of anal melanoma: report of two cases.  Ann Nucl Med. 2006;  20 (9) 629-631
  • 25 Crosby T, Fish R, Coles B, Mason M D. Systemic treatments for metastatic cutaneous melanoma.  Cochrane Database Syst Rev. 2000;  (2) CD001215
  • 26 Chapman P B, Einhorn L H, Meyers M L et al.. Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma.  J Clin Oncol. 1999;  17 (9) 2745-2751
  • 27 Wanebo H J, Fortner J G, Woodruff J, MacLean B, Binkowski E. Selection of the optimum surgical treatment of stage I melanoma by depth of microinvasion: use of the combined microstage technique (Clark-Breslow).  Ann Surg. 1975;  182 (3) 302-315
  • 28 Slingluff Jr C L, Vollmer R T, Seigler H F. Anorectal melanoma: clinical characteristics and results of surgical management in twenty-four patients.  Surgery. 1990;  107 (1) 1-9

Surya P.M. NalamatiM.D. 

Division of Colon and Rectal Surgery, Department of Surgery, Henry Ford Hospital

2799 W. Grand Blvd., Detroit, MI 48202

Email: snalama1@hfhs.org

    >