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Endoscopy 2013; 45(06): 458-468
DOI: 10.1055/s-0032-1326399
Original article
© Georg Thieme Verlag KG Stuttgart · New York

Biodegradable rapamycin-eluting nano-fiber membrane-covered metal stent placement to reduce fibroblast proliferation in experimental stricture in a canine model

Y. Q. Zhu
1   Department of Radiology, The Sixth Affiliated People’s Hospital, Medical school of Shanghai Jiao Tong University, Shanghai, China
,
W. G. Cui
2   School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China
,
Y. S. Cheng
1   Department of Radiology, The Sixth Affiliated People’s Hospital, Medical school of Shanghai Jiao Tong University, Shanghai, China
,
J. Chang
2   School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China
,
N. W. Chen
3   Department of Gastroenterology, The Sixth Affiliated People’s Hospital, Medical school of Shanghai Jiao Tong University, Shanghai, China
,
L. Yan
1   Department of Radiology, The Sixth Affiliated People’s Hospital, Medical school of Shanghai Jiao Tong University, Shanghai, China
,
M. H. Li
1   Department of Radiology, The Sixth Affiliated People’s Hospital, Medical school of Shanghai Jiao Tong University, Shanghai, China
› Author Affiliations
Further Information

Publication History

submitted 28 July 2012

accepted after revision 12 December 2012

Publication Date:
11 April 2013 (online)

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Commentaire de travail de Zhu YQ et al., pp. 458Endoscopy 2013; 45(06): 594-594
DOI: 10.1055/s-0033-1344371

Background and study aims: The aim of the current study was to assess whether placement of the biodegradable rapamycin-eluting nano-fiber membrane-covered metal stent is followed by less fibroblast proliferation and tissue hyperplasia compared with bare stents in experimental stricture in a dog model.

Methods: A total of 80 dog models of stricture were randomly divided into a control group (n = 20, no stent insertion), a bare stent group (BSG, n = 20, 1-week retention), and two drug-eluting stent sub-groups (DESG-1w, n = 20, 1-week retention; DESG-4w, n = 20, 4-week retention). Lower esophageal sphincter (LES) pressure, 5-minute barium height (5-mBH), and cardia diameter were assessed before, immediately after the procedure, and regularly thereafter for 6 months. Five dogs in each group were euthanized for histological examination at each follow-up assessment.

Results: Stent insertion was well tolerated, with similar migration rates (0 % in BSG vs. 7.5 % in DESGs; P = 0.5441). At 6 months, LES pressure and 5-mBH improved in DESG-1w (26.70 ± 5.02 mmHg and 6.50 ± 2.98 cm) and DESG-4w (20.16 ± 5.50 mmHg and 1.54 ± 0.98 cm) compared with BSG (39.94 ± 5.22 mmHg and 11.1 ± 5.46 cm) (P < 0.05), with DESG-4w being more stable than DESG-1w (P < 0.05). The cardia maintained greater patency in the DESGs (7.10 ± 3.09 mm in DESG-1w; 9.16 ± 3.77 mm in DESG-4w) than in the BSG (1.86 ± 2.45 mm; P < 0.05). Reduced peak inflammatory reactions and scarring occurred in DESGs compared with the BSG (P < 0.05), with a better outcome in DESG-4w than in DESG-1w (P < 0.05).

Conclusions: In this experimental stricture model, rapamycin-eluting stents were more effective than bare stents for the reduction of fibroblast proliferation and tissue hyperplasia after stent placement. Furthermore, 4-week retention of the drug-eluting stent led to a better outcome than 1-week retention.

 

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