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Horm Metab Res 2013; 45(11): 834-839
DOI: 10.1055/s-0033-1353187
Humans, Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Dietary Energy Density on Serum Adipocytokine Levels in Diabetic Women

M. Tabesh
1   Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran
,
M. J. Hosseinzadeh
2   Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
,
M. Tabesh
1   Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran
,
A. Esmaillzadeh
3   Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
› Author Affiliations
Further Information

Publication History

received 09 March 2013

accepted 25 July 2013

Publication Date:
26 August 2013 (online)

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Abstract

This study was aimed to assess the effect of dietary energy density (kcal/g) on serum levels of adipocytokines of type 2 diabetic women. In this randomized parallel design clinical trial, a total of 60 diabetic women (aged 30–60 years; BMI>25 kg/m2) were assigned to consume either a low-energy dense (LED) (65% of energy from carbohydrates and 25% from fats), normal-energy dense (NED) (60% from carbohydrates, 30% from fats), or high-energy dense (HED) diet (55% from carbohydrates and 35% from fats) for 8 weeks. The low-energy dense diet was rich in fruits, vegetables, whole grains, and water, while the high-energy dense diet was rich in fats and oils and limited in fruits and vegetables as compared with the normal-dense diet. At baseline and at the end of intervention fasting blood samples were taken to assess metabolic profile. Women in the LED group consumed significantly more dietary fiber (p<0.001), fruits (p<0.001) and vegetables (p<0.001) than those in the NED and HED groups. We failed to find a significant effect of dietary energy density (kcal/g) on serum adiponectin and visfatin levels. Even the within-group changes in serum adiponectin and visfatin levels were not significant. Consumption of LED and NED diets resulted in a significant increase in serum chemerin levels (p=0.04). Comparison of mean changes of serum chemerin levels across 3 groups revealed a significant difference (p=0.04). Our study provides evidence indicating that consumption of HED diet for 8 weeks among diabetic patients prevented the increase in serum chemerin levels compared with LED and NED diets. Furthermore, we found no significant effect of dietary energy density (kcal/g) on serum adiponectin and visfatin concentrations in the current study.

Key words

energy density - diet - diabetes - adipocytokines
 

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