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Endoscopy 2015; 47(11): 1035-1038
DOI: 10.1055/s-0034-1392150
Innovations and brief communications
© Georg Thieme Verlag KG Stuttgart · New York

Initial human experience of endoscopic ultrasound-guided photodynamic therapy with a novel photosensitizer and a flexible laser-light catheter

Jun-Ho Choi   *
1   Division of Gastroenterology, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, South Korea
,
Dongwook Oh   *
2   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Jae Hoon Lee
3   Department of Hepato-biliary and Pancreatic Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Jin-hong Park
4   Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Kyu-pyo Kim
5   Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Seung Soo Lee
6   Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Young-Joo Lee
3   Department of Hepato-biliary and Pancreatic Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Young-Suk Lim
2   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Tae Jun Song
2   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Sang Soo Lee
2   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Dong-Wan Seo
2   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Sung Koo Lee
2   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Myung-Hwan Kim
2   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Do Hyun Park
2   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
› Author Affiliations
Further Information

Publication History

submitted29 October 2014

accepted after revision31 March 2015

Publication Date:
12 June 2015 (online)

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Background and study aims: New methods for the endoscopic selective ablation of locally advanced pancreaticobiliary malignancies as a minimally invasive approach are needed. Our aim was to examine the feasibility and safety of endoscopic ultrasonography (EUS)-guided photodynamic therapy (PDT) for local tumor control in patients with locally advanced pancreaticobiliary malignancies.

Patients and methods: A chlorin e6 derivative and a flexible laser-light catheter were used to perform EUS-guided PDT in four patients with locally advanced pancreaticobiliary malignancies.

Results: EUS-guided PDT was technically feasible in all four patients with locally advanced pancreaticobiliary malignancies (two in the caudate lobe of the liver, one in the far distal bile duct, and one in the tail of the pancreas). No treatment-related complications occurred. The median volume of necrosis produced by PDT was 4.0 cm3 (range 0.7 – 11.3). Disease remained stable in all four patients during a median follow-up of 5 months (range 3 – 7).

Conclusion: These preliminary data suggest that EUS-guided PDT with a second-generation photosensitizer and a flexible laser probe is feasible and safe.

* Jun-Ho Choi and Dongwook Oh contributed equally to this article.


 

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