Semin intervent Radiol 2022; 39(03): 253-260
DOI: 10.1055/s-0042-1751259
Review Article

Advancements in Interventional Oncology of the Chest: Transarterial Chemoembolization and Related Therapies

Jonathan M. Lorenz
1   Department of Radiology, The University of Chicago Medical Center, Chicago, Illinois
,
Rakesh Navuluri
1   Department of Radiology, The University of Chicago Medical Center, Chicago, Illinois
› Author Affiliations

Abstract

While embolization therapy has been used for many years in the treatment of nonmalignant diseases of the chest, such as pulmonary arteriovenous malformation treatment and bronchial artery embolization for hemorrhage, the application of transarterial techniques to the treatment of chest neoplasms is relatively uncommon. Extrapolating from transarterial chemoembolization techniques used for liver malignancy, investigators have recently sought to expand the indications for transarterial techniques from the control of symptoms such as bleeding to the control of disease progression and potentially survival benefit in patients with malignancies in the chest. This article provides an overview of the current embolotherapy techniques used in the treatment of patients with thoracic malignancies.



Publication History

Article published online:
31 August 2022

© 2022. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 de Gregorio MA, Medrano J, Mainar A, Alfonso ER, Rengel M. [Endovascular treatment of massive hemoptysis by bronchial artery embolization: short-term and long-term follow-up over a 15-year period]. Arch Bronconeumol 2006; 42 (02) 49-56
  • 2 Kucukay F, Topcuoglu OM, Alpar A, Altay ÇM, Kucukay MB, Ozbulbul NI. Bronchial artery embolization with large sized (700-900 µm) tris-acryl microspheres (Embosphere) for massive hemoptysis: long-term results (clinical research). Cardiovasc Intervent Radiol 2018; 41 (02) 225-230
  • 3 Panda A, Bhalla AS, Goyal A. Bronchial artery embolization in hemoptysis: a systematic review. Diagn Interv Radiol 2017; 23 (04) 307-317
  • 4 Boas FE, Kemeny NE, Sofocleous CT. et al. Bronchial or pulmonary artery chemoembolization for unresectable and unablatable lung metastases: a phase I clinical trial. Radiology 2021; 301 (02) 474-484
  • 5 Salamonsen M, Tazi-Mezalek R, López-Lisbona R. et al. Combined bronchial artery embolization and endobronchial resection for bronchial carcinoid: a safety and feasibility pilot study. Respiration 2016; 91 (01) 63-68
  • 6 Villanueva C, Doyle M, Berger J, Fermanis G, Glenn D. Surgical removal of an unusual massive mediastinal tumour preceded by interventional embolization. Heart Lung Circ 2017; 26 (02) e7-e10
  • 7 Jesudasan CD, Nair S, Thangakunam B, Keshava SN, Moses V. Near-fatal hemorrhage after bronchoscopic resection of a carcinoid tumor: successful management by bronchial artery embolization. J Bronchology Interv Pulmonol 2010; 17 (02) 152-154
  • 8 Chen J, Chen LA, Liang ZX. et al. Immediate and long-term results of bronchial artery embolization for hemoptysis due to benign versus malignant pulmonary diseases. Am J Med Sci 2014; 348 (03) 204-209
  • 9 Tao H, Sano Y, Yamane M, Toyooka S, Oto T, Date H. Bronchial mucoepidermoid carcinoma with recurrent hemoptysis in a pregnant woman: report of a case. Surg Today 2008; 38 (09) 850-852
  • 10 Kakegawa S, Kawashima O, Ibe T. et al. A case of primary angiosarcoma of the lung presenting as a hemorrhagic bronchial tumor. Ann Thorac Cardiovasc Surg 2012; 18 (04) 347-351
  • 11 de Bucourt M, Streitparth F, Walter T, Teichgräber U. Endometrial stromal sarcoma with selective polyvinyl alcohol embolization of a pulmonary metastasis after recurrent hemoptysis and expansive growth. Rare Tumors 2010; 2 (02) e29
  • 12 Garcia-Olivé I, Sanz-Santos J, Centeno C. et al. Results of bronchial artery embolization for the treatment of hemoptysis caused by neoplasm. J Vasc Interv Radiol 2014; 25 (02) 221-228
  • 13 Razazi K, Parrot A, Khalil A. et al. Severe haemoptysis in patients with nonsmall cell lung carcinoma. Eur Respir J 2015; 45 (03) 756-764
  • 14 Mehta AS, Ahmed O, Jilani D. et al. Bronchial artery embolization for malignant hemoptysis: a single institutional experience. J Thorac Dis 2015; 7 (08) 1406-1413
  • 15 Han K, Yoon KW, Kim JH, Kim GM. Bronchial artery embolization for hemoptysis in primary lung cancer: a retrospective review of 84 patients. J Vasc Interv Radiol 2019; 30 (03) 428-434
  • 16 Fujita T, Tanabe M, Moritani K, Matsunaga N, Matsumoto T. Immediate and late outcomes of bronchial and systemic artery embolization for palliative treatment of patients with nonsmall-cell lung cancer having hemoptysis. Am J Hosp Palliat Care 2014; 31 (06) 602-607
  • 17 Seki A, Shimono C. Transarterial chemoembolization for management of hemoptysis: initial experience in advanced primary lung cancer patients. Jpn J Radiol 2017; 35 (09) 495-504
  • 18 Liu X, Lin H, Wang Q. et al. Drug-eluting beads bronchial arterial chemoembolization plus intercostals arterial infusion chemotherapy is effective and well-tolerated in treating non-small cell lung cancer patients with refractory malignant pleural effusion. J Thorac Dis 2021; 13 (04) 2339-2350
  • 19 Wu H, Zhao W, Liu S, Zheng J, Ji G, Xie Y. Pure transcatheter arterial chemoembolization therapy for intrahepatic tumors causes a shrink in pulmonary metastases of hepatocellular carcinoma. Int J Clin Exp Med 2015; 8 (01) 1035-1042
  • 20 Hori A, Ohira R, Nakamura T. et al. Transarterial chemoembolization for pulmonary or mediastinal metastases from hepatocellular carcinoma. Br J Radiol 2020; 93 (1110): 20190407
  • 21 Seki A, Hori S, Sueyoshi S. et al. Transcatheter arterial embolization with spherical embolic agent for pulmonary metastases from renal cell carcinoma. Cardiovasc Intervent Radiol 2013; 36 (06) 1527-1535
  • 22 Kennoki N, Hori S, Yuki T, Hori A. Transcatheter arterial chemoembolization with spherical embolic agent in patients with pulmonary or mediastinal metastases from breast cancer. J Vasc Interv Radiol 2017; 28 (10) 1386-1394
  • 23 Lorenz JM, Zangan SM, Leef JA. Mediastinal Castleman disease: embolization without surgery. J Vasc Interv Radiol 2009; 20 (10) 1393-1394
  • 24 Miyazaki M, Nakayama A, Noda D, Maehara Y, Tsushima Y. Difficulty in complete transarterial embolization for pulmonary benign metastasizing leiomyoma with massive hemoptysis. Jpn J Radiol 2014; 32 (01) 53-57
  • 25 Perrotta F, Cerqua FS, Cammarata A. et al. Integrated therapeutic approach to giant solitary fibrous tumor of the pleura: report of a case and review of the literature. Open Med (Wars) 2016; 11 (01) 220-225
  • 26 Zhao G, Huang Y, Ye L. et al. Therapeutic efficacy of traditional vein chemotherapy and bronchial arterial infusion combining with CIKs on III stage non-small cell lung cancer. Zhongguo Fei Ai Za Zhi 2009; 12 (09) 1000-1004
  • 27 Huang R, Li WH, Zhu J, Li CL, Wan HG, Chen LZ. [Differences in efficacy between drug-eluting beads transbronchial arterial chemoembolization combined with systemic chemotherapy and systemic chemotherapy alone for unresectable lung squamous cell carcinoma]. Zhonghua Yi Xue Za Zhi 2020; 100 (15) 1164-1168
  • 28 Jin SQ, Zhao HY, Bai B, Ma CH, Cao HL. Transcatheter arterial chemoembolization improves clinical efficacy and life quality of patients with lung cancer and reduces adverse reactions. Am J Transl Res 2021; 13 (09) 10396-10403
  • 29 Luo L, Wang H, Ma H, Zou H, Li D, Zhou Y. [Analysis of 41 cases of primary hypervascular non-small cell lung cancer treated with embolization of emulsion of chemotherapeutics and iodized oil]. Zhongguo Fei Ai Za Zhi 2010; 13 (05) 540-543
  • 30 Shang B, Li J, Wang X. et al. Clinical effect of bronchial arterial infusion chemotherapy and CalliSpheres drug-eluting beads in patients with stage II-IV lung cancer: a prospective cohort study. Thorac Cancer 2020; 11 (08) 2155-2162
  • 31 Bi Y, Shi X, Yi M, Han X, Ren J. Pirarubicin-loaded CalliSpheres® drug-eluting beads for the treatment of patients with stage III-IV lung cancer. Acta Radiol 2022; 63 (03) 311-318
  • 32 Lin H, Wang Q, Tian F. et al. Drug-eluting beads bronchial arterial chemoembolization in treating relapsed/refractory small cell lung cancer patients: results from a pilot study. Cancer Manag Res 2021; 13: 6239-6248
  • 33 Liu XF, Lin H, Wang Q. et al. Drug-eluting bead bronchial arterial chemoembolization vs. chemotherapy in treating advanced non-small cell lung cancer: comparison of treatment efficacy, safety and quality of life. Eur Rev Med Pharmacol Sci 2021; 25 (06) 2554-2566
  • 34 Liu J, Zhang W, Ren J. et al. Efficacy and safety of drug-eluting bead bronchial arterial chemoembolization plus anlotinib in patients with advanced non-small-cell lung cancer. Front Cell Dev Biol 2021; 9: 768943
  • 35 Li YM, Guo RQ, Bie ZX, Li B, Li XG. Sintilimab plus bronchial arterial infusion chemotherapy/drug-eluting embolic chemoembolization for advanced non-small cell lung cancer: a preliminary study of 10 patients. J Vasc Interv Radiol 2021; 32 (12) 1679-1687
  • 36 Yang XG, Wu G, Li ZW. et al. [Efficacy for artery chemoembolization combined with radiofrequency ablation in the treatment of advanced non-small cell lung cancer]. Zhonghua Yi Xue Za Zhi 2016; 96 (07) 539-543
  • 37 Chen C, Wang W, Yu Z, Tian S, Li Y, Wang Y. Combination of computed tomography-guided iodine-125 brachytherapy and bronchial arterial chemoembolization for locally advanced stage III non-small cell lung cancer after failure of concurrent chemoradiotherapy. Lung Cancer 2020; 146: 290-296
  • 38 Chen Y, Li Y, Jia Y. et al. Bronchial artery chemoembolization combined with radioactive iodine-125 seed implantation in the treatment of advanced nonsmall cell lung cancer. J Cancer Res Ther 2017; 13 (04) 636-641