Imaging Recommendations for Diagnosis, Staging, and Management of Hereditary Malignancies

Abstract Hereditary cancer syndromes, characterized by genetically distinct neoplasms developing in specific organs in more than one family members, predispose an individual to early onset of distinct site-specific tumors. Early age of onset, multiorgan involvement, multiple and bilateral tumors, advanced disease at presentation, and aggressive tumor histology are few characteristic features of hereditary cancer syndromes. A multidisciplinary approach to hereditary cancers has led to a paradigm shift in the field of preventive oncology and precision medicine. Imaging plays a pivotal role in the screening, testing, and follow-up of individuals and their first- and second-degree relatives with hereditary cancers. In fact, a radiologist is often the first to apprise the clinician about the possibility of an underlying hereditary cancer syndrome based on pathognomonic imaging findings. This article focuses on the imaging spectrum of few common hereditary cancer syndromes with specific mention of the imaging features of associated common and uncommon tumors in each syndrome. The screening and surveillance recommendations for each condition with specific management approaches, in contrast to sporadic cases, have also been described.


Introduction
Hereditary cancer syndromes (HCSs) are syndromes characterized by genetically distinct neoplasms developing in specific organs in more than one family members, 1,2 predisposing an individual to early onset of distinct site-specific tumors. A radiologist is often the first to apprise the clinician about the possibility of an underlying HCSs based on pathognomonic imaging findings, leading to genetic testing of the individual and their relatives as a part of preventive oncology. Radiogenomics is a term coined in recent years that describes the relationship between imaging features of a lesion and the underlying genetic or molecular abnormality, which aides in approach to diagnosis, guiding therapeutic Keywords ► hereditary cancer syndromes ► radiogenomics ► cancer ► surveillance guidelines

Abstract
Hereditary cancer syndromes, characterized by genetically distinct neoplasms developing in specific organs in more than one family members, predispose an individual to early onset of distinct site-specific tumors. Early age of onset, multiorgan involvement, multiple and bilateral tumors, advanced disease at presentation, and aggressive tumor histology are few characteristic features of hereditary cancer syndromes. A multidisciplinary approach to hereditary cancers has led to a paradigm shift in the field of preventive oncology and precision medicine. Imaging plays a pivotal role in the screening, testing, and follow-up of individuals and their firstand second-degree relatives with hereditary cancers. In fact, a radiologist is often the first to apprise the clinician about the possibility of an underlying hereditary cancer syndrome based on pathognomonic imaging findings. This article focuses on the imaging spectrum of few common hereditary cancer syndromes with specific mention of the imaging features of associated common and uncommon tumors in each syndrome. The screening and surveillance recommendations for each condition with specific management approaches, in contrast to sporadic cases, have also been described.
strategies, assessment of treatment response, and prognostication. 3 Most of the HCSs have an autosomal dominant pattern of inheritance and comprise up to 5 to 10% of the overall worldwide cancer burden. 1,2 Among the Indian population, there is paucity of data on the incidence of hereditary cancers. The mortality rates are possibly higher in India, attributed to different lifestyles, delayed introduction of screening programs, and socioeconomic limitation to treatment access. 4 The lack of knowledge and access to accurate information as well as the social taboo and stigma associated with cancers in India leads to under-reporting and contributes to the skewed incidence. 5 The different genetic mechanisms that play a role in the etiopathogenesis of HCSs include inactivation of tumor suppressor genes or reactivation of proto-oncogenes or abnormalities in the DNA repair genes. 6 Predisposition to certain malignancies and the therapeutic response are determined by the interaction of these genetic mutations with environmental factors called gene-environment interaction. 7 Early age of onset, multiorgan involvement, multiple and bilateral tumors, advanced disease at presentation, and aggressive tumor histology are characteristic of HCSs. A fundamental change in the approach to treatment of hereditary cancers and a paradigm shift to preventive oncology is proof that a multidisciplinary approach with collaboration of clinical, radiological, and pathological specialties with genetic research is a promising step toward precision medicine. The common and uncommon tumors observed in few commonly encountered HCS and their associated mutations have been summarized in ►Table 1. Several childhood cancers are also associated with germline and somatic mutations in cancer predisposition genes. The Society for Pediatric Oncology and Hematology established a CPS (cancer predisposition syndrome) working group that summarized a comprehensive review of childhood CPS and provided clinical and diagnostic recommendations for cancer prevention, surveillance, treatment, and follow-up. 8 Few of the common ones are summarized in ►Table 2.
A comprehensive and standardized guideline structure for screening and management of individuals with suspicion of HCSs is essential. The imaging recommendations for diagnosis and screening of few common HCSs are discussed below.

Hereditary Breast and Ovarian Cancer Syndrome
The most common cancers associated with hereditary breast and ovarian cancer syndrome (HBOCS) are breast and ovarian cancer, as its name suggests. The cumulative cancer risk identified is 55 to 70% for breast cancer and 40 to 45% for ovarian cancer in BRCA1 carriers and 40 to 70% for breast cancer and 15 to 20% for ovarian cancer in BRCA2 carriers. 9,10 The median age at diagnosis for breast cancer is 40 years, compared with 61 years in the general population 11 with a 3% risk of developing breast cancer before the age of 30 years. 12 BRCA-associated breast cancers are usually high grade and poorly differentiated with poorer prognosis. They have a higher growth rate with shorter lead time resulting in more interval cancers. 13 Bilateral cancers are more common in BRCA carriers with an approximately 63% risk of developing a second primary in the contralateral breast. 13,14 More than 80% of BRCA-associated cancers are invasive-ductal type, commonly triple negative (negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2), with a higher than usual incidence of medullary cancers seen in BRCA1 carriers. 11 Higher risk of male breast cancer is also observed in BRCA carriers. 15 Breast density is the single most important quantifiable risk factor that can be rapidly and reliably identified and assessed on mammography. The distribution of breast density in BRCA1 and BRCA2 mutation carriers is similar to that in noncarriers; however, higher breast densities in carriers is associated with an increased risk of breast cancer, with relative risk being similar to that in the general population. 16 Mammographic breast density data has yielded good risk prediction accuracy. 17 BRCA-associated breast cancers usually have benign appearing features, that is, oval well-defined lesions with circumscribed margins on mammogram and ultrasound. Microcalcifications are rarely seen in BRCA1 cancers but seen in up to 40% cases of BRCA2 cancers, similar to sporadic cases. It is optional for women between 40 and 45 years, who are at average risk of breast cancer, to undergo screening mammography, whereas those between 45 and 54 years are strongly recommended to undergo annual mammograms. Those above 55 years can switch to mammograms every other year. Women at high risk, including those with high lifetime risk of breast cancer (> 20%), BRCA or TP53 mutation carriers, first-degree relative with BRCA mutation (with no genetic testing for themselves), and those who have taken radiotherapy to chest wall between 10 and 30 years of age, are recommended to have annual breast magnetic resonance imaging (MRI) with mammograms starting from 30 years of age. Several randomized controlled trials and comparative reviews have studied the advantage of MRI versus mammography for surveillance in high-risk women. Wernli et al found no significant difference in the sensitivity of the surveillance MRI compared with mammography. 18 However, a randomized controlled trial in women at high risk of familial cancer by Saadtmand et al concluded that MRI was advantageous for early-stage cancer detection and decreased the overall breast cancer-related mortality albeit at the cost of high false-positive rate 19 and increased biopsy rates. 18,20 BRCA1-associated ovarian cancers manifest in the fourth or fifth decade of life, 5 to 10 years earlier than sporadic cases, and are usually high grade. 21 Imaging morphology is similar to sporadic cases, that is, heterogeneously enhancing solid masses with areas of hemorrhage, necrosis, and papillary projections. More than 90% cases are serous adenocarcinomas, most commonly arising from the fimbriated ends of the fallopian tubes. 21 They are more sensitive to platinum agents and poly (adenosine 5′-diphosphate-ribose) polymerase inhibitors than sporadic cancers. 22 Survival rate of BRCA2-associated ovarian cancers is known to be better (52%) than BRCA1-associated (44%) and sporadic (36%) cancers. 23 Periodic testing of CA-125 and annual transvaginal ultrasounds are recommended for surveillance of women with familial risk of ovarian cancer. However, many clinical trials including the National Comprehensive Cancer Network guidelines emphasize that they are ineffective in tumor detection and have no substantial influence on survival. 24,25 Thus, currently no screening regimen has proven to be effective in reducing mortality in BRCA-associated ovarian cancers. Risk-reducing salpingo-oophorectomy for prevention of occult neoplasia is the only proven mortality-reducing intervention for women more than 35 years age. 26 Imaging and clinical screening recommendations in BRCA carriers are depicted in ►Fig. 1.

Li-Fraumeni Syndrome
Two criteria exist for diagnosis of Li-Fraumeni syndrome (LFS), the classic and Chompret criteria, summarized in ►Fig. 2, the latter having a higher sensitivity (82-95%) and specificity (47-58%). 27 The lifetime risk of developing cancer with TP53 mutation is nearly 100% for females and 73% for males. 28 The incidence of tumors in LFS is 27 and 16% for soft tissue sarcomas (most common: rhabdomyosarcoma) and osteosarcomas, 60% for breast cancer, 13% for brain and adrenocortical cancers, and 4% for leukemias, respectively. 27,29 Although radiation-induced cancers are rare in the normal population (accounting for less than 5% of all treatment-related cancers), individuals with LFS have increased susceptibility to DNA-damaging effects of ionizing radiation. 30 They are at high risk of developing secondary malignancies in a previously radiated field, with an incidence of 30% and a median time for the development of 10.7 years. 27 In cancer patients testing for TP53 variants, surgical and ablative therapeutic measures are the preferred first-line treatment while advocating the use of non-genotoxic chemotherapeutic agents and avoiding radiotherapy when possible. 31 However, a recent study done by Hendrickson et al did find that the rate of a subsequent malignancy was not significantly different between LFS patients who received radiation compared with those who did not. In fact, none of the subsequent malignancies in patients receiving radiation could be confidently classified as radiation-associated malignancy and were merely considered as disease recurrence. 32 Previously, studies have evaluated the use of 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography (18F-FDG-PET/CT) as a screening tool for LFS; however, increased susceptibility to adverse effects of ionizing radiation negates routine use. 33   tumors in asymptomatic individuals with a 3-year survival rate of 100%, as opposed to 23% in persons who did not undergo surveillance. 35 The cancer detection rate in children with WB-MRI, however, may be lower than adults. 36 Image sequences include coronal T1 and short tau inversion recovery with axial diffusion-weighted images (DWI). Contrast administration is not routinely recommended.
Screening for breast cancers in LFS is done with annual breast MRI. Diagnostic imaging may include mammography but is reserved for older women and is not recommended for young women as the sensitivity of mammography is significantly lower in dense breasts of young women. Breast cancers are usually intraductal type and appear as irregular spiculated solid masses on imaging. Malignant phyllodes is also frequently associated with LFS appearing as a large heterogeneous mass with cystic and necrotic areas of degeneration and marked peripheral and internal vascularity on ultrasound. Women with LFS who develop breast cancer are advised to have bilateral mastectomy rather than lumpectomy to reduce the risk of developing a second primary breast cancer. Also, administration of radiotherapy post lumpectomy is also a challenge since it carries a risk of developing cancer in the radiation field. There is no known elevated risk of male breast cancer.
Almost 50% patients with choroid plexus carcinoma are associated with TP53 alteration. 37 Gliomas like astrocytoma, oligodendroglioma and glioblastoma multiforme are other common brain tumors occurring in LFS. All these have typical features on imaging similar to their sporadic counterparts. Atypical presentation like leptomeningeal spread or involvement of the posterior fossa are encountered. 38  Pediatric patients with adrenocortical cancer almost always have TP53 mutations, appearing as large heterogeneously enhancing masses with metastasis to lungs, liver and lymph nodes on cross-sectional imaging. Screening abdominal ultrasounds are usually sufficient; however, MRI is more sensitive for smaller lesions.
Surveillance recommendations in carriers of germline disease-causing TP53 variants is depicted in ►Fig. 3. 39 von Hippel-Lindau Disease von Hippel-Lindau Disease (VHL) is characterized by the development of vascular tumors due to inactivation of VHL gene that leads to upregulation of somatic and vascular growth factors, including vascular endothelial growth factor (VEGF). Renal, central nervous system, and pancreas are the most commonly involved organ systems.
The most common malignancy associated with VHL is renal cell carcinoma (RCC). Early diagnosis of RCC is imperative as they are known to be multiple, prone to relapse, and also the most common cause of death. Diagnosis as well as screening for RCCs utilizes the renal imaging protocol on CT (with unenhanced, cortico-medullary, nephrogenic, and excretory phases) which is the gold standard for depiction of characteristic vascular lesions showing arterial enhancement and venous wash out. MRI is increasingly preferred over CT for imaging in VHL owing to the absence of ionizing radiation, superior evaluation of smaller lesions, improved detection of intratumoral lipid, and hemorrhage and safer use with renal impairment. A recent study by Farhadi et al in 2020 correlated the relationship between apparent diffusion coefficient (ADC) and the growth rates of RCC for predicting the volume doubling time (VDT); ADC bearing a negative relationship with growth rate and positive relationship with VDT, thus, establishing the use of DWI in identifying RCCs with higher growth rates. 40 Imaging also plays an important role in targeted intervention. Percutaneous focal ablation, like CT-guided radio frequency ablation (RFA) and cryoablation, is the preferred treatment for RCCs in VHL as it significantly improves the cancer-free survival, 41 especially for smaller (< 3 cm) and multiple tumors. Nephrectomy is not recommended; however, for tumors larger than 3 cm, nephron-sparing surgery may be performed. 41 Some prefer to use a cutoff of 4 cm for surgery as this may help delay the surgery time. 42 About 70% cases of VHL exhibit hemangioblastomas in the central nervous system, usually multiple with a high rate of recurrence, seen with decreasing frequency in the cerebellum (52%), spinal cord (cervical or thoracic) (44%), and brain stem (18%). 43 On MRI, intense hypervascular enhancement of mural nodule is seen with tumor-related cysts showing nonenhancing walls. Calcification is characteristically absent. Spinal MRI screening for spinal hemangioblastomas is mandatory in the presence of cerebellar hemangioblastoma as they usually coexist. Retinal hemangioblastomas are found in 70% of cases over the age of 60 years. Diagnostic workup includes ophthalmoscopy and fluorescein angiography, the role of imaging being limited. MRI may depict a  There are two subtypes of VHL, depending on the absence (type 1) and presence (type 2) of pheochromocytoma. VHL exhibits a distinct pattern of plasma catecholamine excess, almost exclusively norepinephrine production, as compared with combination of metanephrine and normetanephrine in MEN2 or NF1. 44 On cross-sectional imaging, pheochromocytomas show avid early arterial enhancement with venous washout. Calcification as well as areas of necrosis and hemorrhage may be seen. Radionuclide meta-iodobenzylguanidine (MIBG) scan can be used for tumor localization as well as detection of occult metastasis. Recent studies have showed that the diagnostic accuracy of WB-MRI is comparable to that of MIBG. 45 Endolymphatic sac tumors are associated with VHL in mere 20% cases; however, bilateral occurrence is pathognomic and can be detected on contrast-enhanced MRI of the brain and internal auditory meatus.
Pancreatic serous cystadenomas and neuroendocrine tumors (NET) are also common, with the latter harboring a malignant potential and detected in up to 15% patients with VHL. 46 Serous cystadenomas have the typical appearance of "cluster of small cysts" with a central scar identified on crosssectional imaging. They require no treatment unless symptomatic. NETs have the typical early arterial enhancement and venous washout like other hypervascular NET on crosssectional imaging and are seen most commonly in the head and uncinate process of pancreas. Endoscopic ultrasound with or without contrast has a significant role in the diagnosis, intervention (tissue sampling and/or targeted ablation) and surveillance of NETs in VHL. 47 MRI has increased sensitivity over CT and the use of DWI has significantly improved the sensitivity of tumor detection, comparable to PET/CT wherein low ADC values suggest higher grade tumor. 47 68 Ga-DOTATATE PET/CT is useful for the depiction of small NETs, whereas 18 F-FDG-PET/CT has increased sensitivity for higher grade tumors. 47 Tumor-to-tumor metastasis is a peculiar phenomenon associated with VHL and refers to the spread of malignant cells from RCC, NET, and pheochromocytoma to existent hemangioblastomas, which act as a host for metastases, 48 suspected with sudden change in size of hemangioblastomas.
Systemic chemotherapeutic treatment in few VHL patients with inoperable or previously treated lesions is recommended, like VEGF-receptor inhibitor and fibroblast growth factor inhibitor.
Summary of individuals who should be tested for VHL mutation is given in ►Fig. 4.

Multiple Endocrine Neoplasia Syndrome
Multiple endocrine neoplasia (MEN) syndrome is a group of autosomal dominant cancer syndromes characterized by the simultaneous presence of neoplasms in two or more endo-crine organs. 52 There are two types: MEN 1 (Wermer's syndrome) and MEN2. MEN1 affects all age groups without any gender predilection with a prevalence of 2/100,000. 53 MEN2 has a prevalence of 1/200,000 live births. 54 The associated abnormalities in MEN syndromes have been summarized in ►Fig. 6.

MEN1
MEN1 constitutes many endocrine and nonendocrine tumors; however, approximately one-third of deaths in MEN1 are caused by endocrine malignancies. The crux of the management lies in early diagnosis and intervention that lead to improved outcome and decreased morbidity. Recommendations suggest performing genetic testing in individuals with significant family history or when the clinical presentation is suggestive of MEN1, supplemented with regular biochemical screening and cross-sectional imaging in patients who harbor the mutation. 55 Parathyroid adenomas are the most common tumors in MEN1 (100% cases), presenting with elevated parathormone and hypercalcemia, usually before the age of 20 to 25 years. On ultrasound, which is usually the first investigation, they appear as nodular hypoechoic masses with increased vascularity. Asymmetric uptake and retention on delayed images of 99m Tc-sestamibi nuclear scintigraphy are pathognomic. The sensitivity and positive predictive values of ultrasound and nuclear scintigraphy are similar. Increased sensitivity of four-dimensional CT is observed especially with smaller lesions and multigland involvement. 56 Dynamic MRI is superior to CT for demonstrating the hypervascular nature of parathyroid adenomas. Contrast-time curve generation allows quantitative analysis of the perfusion parameters of parathyroid adenomas and reveals a faster time-to-peak, higher peak enhancement, and faster wash in washout compared with cervical lymph nodes or thyroid, thus improving the diagnostic accuracy. 57 Hyperparathyroidism is treated with surgery, usually entailing excision of three and a half gland (subtotal parathyroidectomy) in cases where all the four glands are affected.
Enteropancreatic NET, seen in 30 to 70% cases, is a cause of significant morbidity and mortality in MEN1 syndrome as most of them are functional, however, with a lesser malignant potential. Transabdominal ultrasound is usually the first investigation performed. Endoscopic ultrasound has a higher sensitivity (100%) and specificity (95%), but is invasive and depends on operator efficiency. Cross-sectional imaging is most widely performed for diagnosis and staging. Most common are gastrinomas, frequently occurring in the duodenum, and tend to be multiple. Patients are usually offered non-surgical treatment except for cases with secretory tumors, pancreatic origin and size more than 2 cm. Patients with insulinoma, VIPoma, and glucagonoma are offered surgery. 58 A high incidence of anterior pituitary tumors is observed in women with MEN1 (30-40%). 59 They are usually microadenomas (two-third cases) and best visualized on MRI, as small hypointense lesions on T1. Dynamic post-contrast sequence acquisition is essential for their depiction. 68 Ga-DOTATATE PET/CT can identify functioning and nonfunctioning pituitary adenomas, although it is most useful in  detecting residual normal pituitary tissue after adenomectomy and for diagnosis of recurrence of functioning adenomas. 60 Treatment remains similar to sporadic cases.

MEN2
MEN2A (Sipple's syndrome) is more common and MEN2B is less common but more aggressive.  68 Ga-somatostatin analogs PET/CT is suboptimal. 62 Surgery is the best form of prevention as well as cure for MTC with regular postoperative monitoring of serum calcitonin to detect recurrence. Early thyroidectomy may lower the mortality from hereditary MTC to less than 5% 63 with a more aggressive neck dissection for successful cure. There may be an association of benign or malignant pheochromocytomas in MEN2 syndrome. Therefore, once the germline RET mutation is confirmed, it is important to rule out the presence of a pheochromocytoma. If crosssectional imaging is nondiagnostic or depicts a unilateral disease, functional imaging like MIBG is suggested that has a higher sensitivity (87-90%). The screening for pheochromocytomas should be started in childhood, age of onset varying according to the risk category of mutation. Screening consists of measuring free plasma and 24-hour urine metanephrine and nor-metanephrine supplemented with cross sectional imaging if these levels are high. In cases with synchronous presentation of MTC and pheochromocytoma, pheochromocytoma should be treated first, followed by MTC. 64 Adrenalectomy is the treatment of choice following adrenal blockade. Parathyroid tumors are seen in MEN2A and require investigations similar to MEN1 syndrome. Hyperparathyroidism does not develop in MEN2B, and thus screening is not required.
Guidelines for biochemical and radiological screening in individuals at high risk of developing MEN2 are depicted in ►Fig. 8. 61

Tuberous Sclerosis
Tuberous sclerosis (TSC) is a neurocutaneous syndrome. The classic clinical triad for diagnosis includes facial adenoma sebaceum, epilepsy, and mental retardation, seen in 30 to 40% cases. The clinical diagnosis of TSC is divided into major and minor features summarized in ►Fig. 9.
The most common intracranial manifestation of TSC is cortical tubers or hamartomas, seen in 95% cases. On CT, they are hypodense areas of gyral widening. Calcification may be seen with progression. On MRI, they are T1 hypoin-tense and T2 hyperintense with contrast enhancement in 10% cases. Microstructural changes in the tubers are detected by diffusion tensor imaging. 65 Occasionally, a cyst-like appearance may be seen on MRI following evolution of cortical tubers. These are associated with more severe epilepsy phenotypes. Cortical tubers associated with refractory epilepsy often require surgery. Pulsed arterial spin-labeled technique helps in quantifying perfusion characteristics of cortical tubers. Hyperperfused lesions are associated with increased frequency of seizures. 66 Preoperative evaluation with 18 F-FDG-PET/MRI for TSC has emerged as an indispensable noninvasive method to select the tubers as surgical candidates in refractory epilepsy. 67 Evaluating the involvement of perituberal cortex on MRI is essential for defining the extent of resection. 68 Subependymal nodules are also common and appear isointense on T1 and iso-to hyperintense on T2 more and are more prone to calcification than cortical tubers. Radial migration lines are the most common white matter abnormality identified in TSC.  Subependymal giant cell astrocytoma (SEGA) is defined as a lesion more than 1 cm in size at the caudothalamic groove or a subependymal lesion showing serial growth. 69 It is the most common central nervous system tumor in TSC, seen in 10 to 15% cases. It presents in late childhood and remains asymptomatic unless complicated with hydrocephalus. On MRI, they are hypo-to isointense compared with cortex on T1 and heterogeneously iso-to hyperintense on T2, most of them showing contrast enhancement. Early surgical resection is the standard treatment. Medical management with mechanistic target of rapamycin (mTOR) inhibitors is currently indicated for patients with symptomatic SEGA that are not amendable to surgery. 70 Lymphangioleiomyomatosis (LAM) is characterized by multiple thin-walled cysts scattered in lungs. Strong female preponderance is noted with symptoms developing in the middle age. TSC association is seen in approximately 15% cases of LAM. Solitary or multiple cardiac rhabdomyomas are seen in approximately 60% of children, but only 20% of adults, and are usually asymptomatic. On MRI, they are well-defined masses on the ventricular septum, isointense to myocardium on T1, and hyperintense on T2. Although surgical excision is the mainstay of treatment, mTOR inhibitors can be used as a temporary treatment for symptomatic cardiac rhabdomyomas in TSC, especially in high risk and inoperable cases. 71 About 20% case of renal angiomyolipoma (AML) are associated with TSC. Presence of fat within AML can be demonstrated on CT, but best appreciated on T1 in-and opposedphase images. Evaluation of lipid-poor AMLs can be a challenging and needs differentiation from RCC that is not uncommon in TSC. Multifocal and bilateral AMLs pose a challenge for surgical management, and thus RFA or cryoablation techniques are employed, especially for smaller tumors. mTOR inhibitors are used preoperatively that cause a significant reduction in size of lesions (38-95%) and reduce the risk of recurrence. 72 The International Tuberous Sclerosis Complex Consensus Group reviewed the 2013 surveillance and management recommendations and published updated guidelines in 2021. 73 They have been summarized in ►Fig. 10.

Conclusion
Identification and diagnosis of hereditary syndromes and genetic predisposition syndromes require an integrated approach of clinical evaluation, genetic testing, and radiological screening and surveillance. Surveillance recommendations have been developed for different HCSs over years based on the spectrum of associated cancers with the aim of prevention and early diagnosis. National and international collaboration to build cancer registries will be crucial for an evidenced-based and targeted approach to genetically predisposed individuals.