Imaging of Non-malignant Conditions of the Prostate and Seminal Vesicles: A Comprehensive Review

Abstract Non-malignant conditions of the prostate and seminal vesicles are much more common in imaging practice than prostate cancer. They include benign prostatic hyperplasia, infective and inflammatory prostatitis, prostatic and periprostatic cysts, and benign tumors. The advances in magnetic resonance imaging (MRI) of the prostate gland have dramatically improved the ability to identify these entities, many of them being identified incidentally in patients evaluated for other indications. Good knowledge of these conditions can aid in precise diagnosis and avoid interpretation pitfalls. In this article, we present non-malignant conditions of the prostate gland using several imaging modalities, including transrectal ultrasound, MRI, and computed tomography. We also present the pathological correlation for benign tumors.


Introduction
Non-malignant conditions of the prostate and seminal vesicles (SVs) are common in clinical practice and often detected incidentally while reporting imaging studies.These include age-related changes such as benign prostatic hyperplasia, congenital and acquired prostatic and periprostatic cysts, infective and inflammatory changes in the prostate, and benign neoplasms.In multi-parametric MRI (mpMRI) of the prostate, many of these entities contribute significantly to pitfalls in image interpretation.2][3][4] Knowledge of their clinical presentation and imaging appearances can help accurate image interpretation and guide clinical referrers to optimal management.In this review, we present common non-malignant pathologies of the prostate and SVs and discuss the clinical presentation and their imaging appearances in different imaging modalities.

Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH) refers to an increase in the number of prostatic stromal and epithelial cells in the transition zone (TZ) and periurethral glands that cause the formation of discrete nodules and prostate enlargement. 5It develops in response to testosterone after it is converted to dihydrotestosterone. 6 Its prevalence increases with age and affects approximately 75% of men older than 70 years. 5BPH can cause bladder outlet obstruction leading to lower urinary tract symptoms like urgency, frequency, weak stream, and nocturia.
Imaging modalities in BPH include transabdominal ultrasound, transrectal ultrasound (TRUS), and MRI.Computed tomography (CT) scan has limited value as it does not accurately define prostatic zonal anatomy.Transabdominal ultrasound is the standard first-line investigation for BPH and shows an increase in a prostate volume exceeding 25cc.The central gland is enlarged with hypoechoic or mixed echogenicity.There may be significant postvoid residual urine and associated bladder wall hypertrophy and trabeculations due to chronic bladder outflow obstruction.
On TRUS, BPH appears as a diffuse or nodular enlargement of the TZ, periurethral glandular tissue, or both. 7Hyperplastic nodules are usually hypoechoic to peripheral zone (PZ) tissue but may be isoechoic or hyperechoic depending on the amount of fibrous, muscular, and glandular hyperplastic elements and are surrounded by fibrous envelopes that appear as hypoechoic rims (►Fig. 1). 7On MRI, BPH appears as band-like areas and/or encapsulated circumscribed round nodules in the TZ.While predominantly glandular nodules appear T2 hyperintense, stromal nodules may appear T2 hypointense and contribute to a substantial number of PIRADS 3 lesions in clinical practice. 6The heterogeneous appearance of TZ on T2 due to both hyperintense and hypointense BPH nodules is likened to "organized chaos" (►Fig. 2).BPH nodules showing complete T2 hypointense rim are categorized as typical BPH nodules (PIRADS 1), while those showing partial encapsulation are atypical nodules   Early disease is managed conservatively with alpha-blockers and 5-alpha reductase inhibitors.Surgical management for symptomatic patients is achieved with transurethral resection of the prostate (TURP).Laser-based and thermal ablation procedures and prostatic artery embolization may also reduce periurethral prostatic volume and obstruction. 8Any procedure that does not completely remove the TZ has the potential for recurrence and may result in the need for an additional procedure.

Infections and Inflammatory Diseases
Prostatitis is inflammation or infection of the prostate and clinically presents with symptoms referable to the lower urogenital tract and perineum.Studies suggest the prevalence  of prostatitis is 2 to 16%. 11The National Institutes of Health classifies prostatitis into four categories-acute bacterial prostatitis, chronic bacterial prostatitis, chronic prostatitis or pelvic pain syndrome, and asymptomatic inflammatory prostatitis. 12

Acute Prostatitis
Acute prostatitis has a bimodal age distribution affecting men of 20 to 40 years and over 60 years. 13,14The most common pathogen is Escherichia coli (in 60%), followed by Pseudomonas aeruginosa and Enterococcus species. 15,16The infection spreads as ascending urethral infection, direct seeding from prostatic biopsy, intraprostatic reflux of infected urine, or by hematogenous spread as in sepsis and tuberculosis.About 6% of acute bacterial prostatitis can progress to prostatic abscesses in whom imaging is indicated. 17Patients with acute prostatitis who do not respond to treatment after 48 hours should be evaluated for a possible prostatic abscess. 18rostatic abscess appears as a hypoechoic area with internal septae and thick well-defined walls on TRUS (►Fig. 4); TRUS is also of value in ultrasound-guided drainage of abscess (at least 18G needle is preferred).Unroofing/transurethral drainage of the prostatic abscess is preferred in lesions too large to drain percutaneously or lesions that do not respond to percutaneous drainage. 19Contrastenhanced CT shows an edematous appearance of prostate and periprostatic stranding.Prostatic abscess appears as hypodense focus with peripheral enhancement and internal septations (►Fig.5). 20Cross-sectional imaging also gives valuable information regarding extraprostatic spread.MRI offers better soft tissue resolution than CT and is more sensitive than TRUS in the early stages of abscess formation.Abscess shows a low signal on T1, high signal on T2-weighted MRI, central diffusion restriction and displays peripheral rim enhancement with gadolinium. 20rostate must be carefully reviewed in patients with cystitis with persistent fever in the absence of upper urinary tract infection (UTI), recurrent UTI in the absence of renal involvement/structural abnormalities of the urinary tract, secondary peritonitis, immunocompromised, diabetic patients, and those with sepsis (►Figs. 1 and 2).Prostatic abscess carries high morbidity and mortality and needs a  high index of suspicion, and imaging is critical for timely diagnosis and treatment.

Chronic Prostatitis
It encompasses a spectrum of etiologies from a sequel to acute prostatitis, and recurrent UTIs to IgG4-related disease and tuberculous prostatitis.Chronic prostatitis appears as wedge-shaped T2 hypointense lesions with a linear pattern in the peripheral zone with or without capsular retraction and does not show diffusion restriction (►Fig.6).Granulomatous prostatitis (GP) is a nodular form of chronic prostatitis.It can be idiopathic, tuberculous, iatrogenic due to Bacille Calmette-Guerin (BCG) vaccine, intravesical BCG for bladder cancer, postradiotherapy or due to autoimmune aetiologies and systemic conditions like sarcoidosis. 21GP demonstrates a tumor-like morphology, with nodular or diffuse hypoechogenic lesions on ultrasound, and has PIRADS 5 appearance on mpMRI. 22On T2-weighted MRI, GP lesions appear hypointense like prostate cancer.GP and cancer lesions share high signal intensity on high b-value DWI and low signal intensity on the ADC map.On DCE-MRI, GP shows moderate persistent enhancement and prostate cancer shows early enhancement and rapid washout due to increased vascularity. 23GP is more commonly diffuse when compared to prostate cancer.Unlike the diffuse forms of prostate cancer, in GP the prostatic capsule is usually intact (►Fig. 7).Clinical profile combined with declining serial prostate-specific antigen (PSA) value in some cases may hint the radiologist to a diagnosis of GP over malignancy.

Prostatic and Periprostatic Cysts and Their Mimics
Prostatic and periprostatic cysts are uncommon pathologies often encountered as incidental findings on imaging. 24These are mostly asymptomatic but sometimes may present with lower urinary tract symptoms and infertility. 24Knowledge of embryology and anatomical localization by high-resolution MRI helps in characterizing these lesions.

Prostatic Utricle and Müllerian Duct Cysts
The Müllerian duct is an embryonic structure that normally regresses in males, except for a part at its cephalic end that contributes to remnant structures such as the prostatic utricle and testicular appendix. 25A prostatic utricle cyst is Fig. 6 A 65-year-old male with lower urinary tract symptoms, an enlarged prostate gland, and a hard right-sided nodule palpable on clinical examination.Prostate-specific antigen was 0.88 IU/mL.(A, B) High-resolution T2 axial and coronal images showed a wedge-shaped T2 hypointense lesion with a striated appearance in the anterio-lateral and posterio-lateral peripheral zone in the right mid-gland.(C, D) Diffusionweighted imaging (b1500) and apparent diffusion coefficient map showed no diffusion restriction.Based on these imaging features, magnetic resonance imaging was reported as PIRADS 2, likely changes of chronic prostatitis.
a cystic dilatation of the prostatic utricle.Müllerian duct cysts are cystic dilatations of segments of the Müllerian duct that failed to regress.
Ultrasonography, CT, and MRI can detect these cysts.The anatomic location, shape of the cyst, and relationship with the urethra can aid in distinguishing between prostatic utricle cyst and Müllerian duct cyst as summarized in ►Table 2. MRI has the advantage of superior soft tissue resolution and high-resolution images can assess relationships with adjacent structures better (►Fig.8). 26,27anagement decisions are based on the size of the cyst, its location, and the symptoms of the patient.Cysts larger than 2.5 cm are usually symptomatic and may need urology referral and further management.These cysts can bleed or get secondary infection and very rarely can transform into malignancy. 26Management options for Müllerian duct cysts include surveillance, TRUS-guided aspiration and injection of sclerosing agents, surgical excision, transurethral resection, and percutaneous aspiration.Laparoscopic excision has also been tried. 24,27jaculatory duct cysts Ejaculatory duct cysts usually develop secondary to ejaculatory duct obstruction 25 and can be congenital or acquired.24 The ejaculatory duct is a short, approximately Fig. 7 A 58-year-old male with prostate-specific antigen (PSA) of 5 IU/mL from elsewhere and a repeat PSA at our center 8 weeks after the previous PSA of 1.64 IU/mL.Multi-parametric magnetic resonance imaging (MRI) of the prostate was done.  2 cm long structure coursing through the central zone of the prostate gland and formed by the joining of duct from the SV and ductus deferens.On imaging, these are seen as paramedian cysts (►Fig. 9A, B in the central zone along the ejaculatory duct.25 Larger lesions may extend above the prostate gland and appear as midline lesion.25,26 The obstructed ejaculatory duct causes proximal dilatation of the duct depending on the level of obstruction and extent of fibrosis.There can also be ipsilateral prominence of vas deferens, dilatation of SV ducts, and enlargement of SV.High-resolution MRI is helpful in localizing the level of obstruction.25 Due to limited availability and cost factors, MRI is reserved for cases with inconclusive ultrasonography.25 Aspirate shows spermatozoa, and fructose and may rarely contain calculi.26 The treatment is usually surveillance and surgery is considered in symptomatic patients or those with infertility.Prostatic retention cysts (PRC) and cystic degeneration of BPH These are usually seen in the region of glandular tissues of the prostate gland, mostly asymptomatic, and encountered during the 5th to 6th decades of life.25 The exact etiology of PRC is unknown, but is seen frequently in patients with BPH 25 and could be the result of obstruction of the prostatic parenchymal ductules.26 On imaging, these are round,  smooth unilocular cysts and can occur in any prostatic zone, usually the peripheral zone with or without background changes of BPH (►Fig.10A, B).Cystic degeneration of BPH nodules results in irregularly shaped cysts commonly seen in the TZ of the prostate gland (►Fig.10C).
Tumoral cysts Some tumors like multilocular prostatic cystadenoma and adenocarcinoma also show cystic changes along with soft tissue components. 24,28) Periprostatic cysts Periprostatic cysts include SV cysts, cyst of vas deferens, and Cowper's duct cysts. 24eminal vesicle cysts These can be congenital or acquired and may be associated with adult polycystic kidney disease. 26,27These are mostly detected incidentally unless they are large enough to cause obstructive urinary symptoms. 29They occur commonly in sexually active males secondary to a malformed or stenosed duct system. 27When congenital, they develop due to atresia of ejaculatory ducts and thereby, are associated with bulky distended SV.Congenital cysts are mostly unilateral and associated with anomalies like renal agenesis, ectopic ureteric insertion, and vas deferens agenesis.Zinner syndrome is a triad of unilateral renal agenesis, ipsilateral SV cyst, and ejaculatory duct obstruction 27 (►Fig.11).On imaging, they appear as well-defined round/oval/tubular cysts within the SV, posterior to the urinary bladder. 26,29In cases of hemorrhage and proteinaceous content, they appear hyperintense on T1-weighted imaging and hypointense to bladder contents on T2 weighted imaging (►Fig. 11). 27On TRUS, they are seen as anechoic cystic lesions within the SV with variable echogenicity in the presence of hemorrhage or proteinaceous content. 27,29These cysts are usually treated with conservative management.However, TRUS-guided cyst drainage can be done if symptomatic.

Cysts of the vas deferens
Ductus deferens, formerly called vas deferens, is a muscular tube that transports sperm from epididymis to ejaculatory ducts.These cysts are seen along the ductus deferens and cranial to the prostate gland and posterior to the urinary bladder. 27,28On MRI, these are seen as well-defined T1 hypointense, T2 hyperintense fluid signal thin-walled cysts and are not easily confused with other differentials 26,27 due to their location along the course of the ductus deferens.

Cowper's (bulbourethral) duct cysts
Cowper's glands are paired structures located on either side of the urogenital diaphragm at the level of the membranous urethra. 30Secretions from each gland drain into individual ducts that join to form a single duct that empties into the proximal bulbar urethra. 31The dilatation of the duct called syringocele is very rare and develops due to duct obstruction.
Based on its communication with the urethra, it is divided into open type and closed type. 30These can be congenital or acquired, and encountered more often in pediatric population.The majority of them are asymptomatic.Symptoms if present include recurrent UTIs, voiding problems, dysuria, and palpable perineal mass. 32On imaging, these are seen as well-defined midline or paramedian cysts that appear anechoic on ultrasound and hyperintense on T2-weighted MRI, located posterior to the posterior urethra and inferior to the prostatic apex 27 (►Fig.12).Asymptomatic or mildly symptomatic cases are kept under surveillance and patients with severe symptoms are managed by endoscopic deroofing of  iii) Mimics of prostatic and periprostatic cysts Ureteroceles, dilatation of the prostatic urethra after TURP, bladder diverticula, hydroureter and ectopic insertion of the ureter (►Fig. 13)are mimickers of prostatic and periprostatic cysts and the differentiating features 2,4 have been tabulated in ►Table 3.

Benign Neoplasms of Prostate and Seminal Vesicles
A wide variety of neoplasms, both benign and malignant can occur in the prostate and SV. 34Malignant neoplasms are much more common than benign neoplasms, with acinar adenocarcinoma being the most common neoplasm.Benign neoplasms are of mesenchymal origin and constitute less than 1% of all tumors. 35They generally are large lesions that cause nonspecific and chronic lower urinary tract symptoms.PSA levels will usually be normal in these neoplasms because PSA is produced by epithelial cells of the prostate, which enter the bloodstream when the blood epithelial barrier is destroyed.

Stromal Tumors of Uncertain Malignant Potential
Prostatic stromal tumors of uncertain malignant potential (STUMPs) are rare stromal tumors with unpredictable biological behavior.They are reported to occur in adults of any age, with the highest prevalence in the 6 th to 7th decades.These mimic periprostatic cysts when located along the prostate or seminal vesicle Communication of these cysts with the urinary bladder confirms the diagnosis Based on the histologic appearance, there are five patterns of STUMPs. 34The most common pattern is a lesion with hypercellular stroma with scattered atypical but degenerativelooking cells admixed with benign prostatic glands.A distinctive pattern of STUMP is the phyllodes subtype, with a leaf-like growth pattern.Stromal tumors are positive for CD34 and progesterone receptors and uncommonly express estrogen receptors.STUMPs commonly arise from the peripheral zone rather than the TZ of the gland and appear as a solitary, sharply circumscribed, solid or solid-cystic mass with solid areas showing T1 hypointense and T2 hyperintense signal (►Fig. 14)on MRI. 36The cystic component can be clear fluid, mucinous, or blood.A rim-like hypointense "capsule" is characteristically seen on T2-weighted images (►Fig. 14).The solid components of the lesion show gradual enhancement on DCE-MRI.Large tumors may invade adjacent organs such as the rectum and there are case reports of metastases to the lungs and bones. 37The differential diagnosis includes BPH nodules, cystadenoma (►Fig. 18),sarcomas, and other mesenchymal lesions.Treatment of STUMP is complete surgical resection; however, they frequently recur (up to 65%). 37

Benign Nonstromal Mesenchymal Tumors
Benign non-stromal mesenchymal tumors arise from smooth muscle elements in prostatic stroma or peri glandular tissue.Leiomyoma, schwannoma, solitary fibrous tumor (SFT), inflammatory myofibroblastic tumor (IMT), and paragangliomas are benign mesenchymal tumors reported to arise from prostate and are very rare. 36Generally, they have non-specific imaging features and need a biopsy for a definitive diagnosis.The differentiation between benign and malignant mesenchymal tumors also may be difficult unless there is definite evidence of local invasion or metastasis.
Leiomyoma arising within the gland can resemble the stromal nodule of BPH if it is small, though most of them are very large at presentation. 38Imaging shows a well-defined, solitary, solid mass with predominantly homogeneous enhancement.At MRI, T1 and T2-weighted images have low signal intensity and homogeneous enhancement when small, but large lesion can be heterogeneous on T2 and postcontrast images due to necrosis (►Fig.15).Expression of smooth muscle actin and desmin confirms the diagnosis, while CD34 is negative, distinguishing it from STUMP. 39chwannomas typically arising in the 4 th to 6th decades are commonly sporadic.A smaller proportion can be associ- ated with hereditary syndromes like neurofibromatosis type 2 and schwannomatosis. 40On CT, sporadic schwannomas are typically well-circumscribed solitary oval masses with cystic changes, calcifications, and variable enhancement.MRI usually shows low T1 signal intensity, heterogeneous high T2 signal, and variable post contrast enhancement. 41,42FToriginating from prostate is rare and have been reported previously among different age group ranging from 21 to 75 years.They are generally large lesions over 5 cm and may induce paraneoplastic syndromes like hypoglycemia (Doege-Potter syndrome) due to tumor-secreted insulin-like growth factor-2. 43,44On MRI, SFT appears hypointense on T1-weighted images and displays mixed heterogeneous signal intensity on T2-weighted images, dependent on collagen or other components.Gradual post enhancement is seen owing to fibrous content.Diffusion restriction may indicate areas of high cellularity (►Fig.16). 45Surgical removal remains the primary treatment; however, recurrence is reported in 10 to 30% of cases. 46rostate IMT has been reported between ages 21 to 83 years. 38,47They appear hypointense on T1-weighted images and mixed heterogeneous onT2-weighted images depending on fibrosis and inflammation.Contrast-enhanced CT and MRI can display avid, homogeneous, or heterogeneous enhancement. 36ostate paragangliomas are rare tumors derived from extra-adrenal chromaffin cells in sympathetic or parasympathetic paraganglia.They can have sporadic or familial occurrences (linked to syndromes like MEN 2A/B, von   Hippel-Lindau, neurofibromatosis type 1, Carney complex, and familial paraganglioma syndromes).Functioning types may exhibit catecholamine-related symptoms. 48,49In contrast to CT and MRI, paraganglioma appears as hyper enhancing lesion reflecting the richly vascularized nature of these tumors.At MRI, paragangliomas typically show marked T2 hyperintensity with classic salt-and-pepper appearance due to multifocal signal voids.They tend to have high signal intensity at high b-value DWI, but the signal on the ADC map is not reduced or only mildly reduced.PET imaging with 68Ga DOTATATE will show marked avidity.

Ectopic Prostate Tissue
Ectopic prostatic tissue (EPT) is defined as the presence of prostatic tissue at sites other than the prostate.It is mostly reported in the urethra and bladder and less commonly reported in the genital tract involving SV, epididymis, and testis. 50,51There are case reports of EPT described in other locations, including the bowel, 52 pelvis, 53,54 and spleen. 55he origin of this around the lower urinary tract is believed to be vestigial remnants of developmental migration, while other sites may involve metaplasia or misplacement of prostate glands during development. 51Clinical manifestations of EPT in the lower urinary tract include hematuria or urinary obstruction.EPT in the rest of the sites is either asymptomatic or has non-specific symptoms. 51Prostate hyperplasia and neoplasms developing in EPT have been reported. 51,52MRI shows the typical signal intensity of the prostate gland with or without hyperplasia and ►Fig. 17is an example of EPT in the right distal ureter.The symptomatic patients are managed surgically.

Cystadenoma of the Prostate and Seminal Vesicle
Cystadenoma of the prostate and SV are rare benign multilocular cystic tumors.Though the same nomenclature is used for both prostate and SV lesions, they are classified separately in the World Health Organization classification with some differences in pathology. 34These lesions are reported in patients between 16 and 80 years and are usually large lesions measuring over 7 cm. 36They cause obstructive and irritative urinary symptoms due to their large size.The serum PSA level is often elevated in prostate cystadenoma while always normal in SV cystadenoma.Histological examination shows cysts lined by cuboidal cells without atypia in the background hypocellular stroma. 34Immunohistochemical staining will be positive for PSA and prostate-specific acid phosphatase in prostate cystadenoma while they are negative in SV cystadenoma.Imaging helps in determining the epicenter of lesion (prostate or SV).and 19). 56The cyst contents can range from simple fluid, to non-simple hemorrhagic or proteinaceous fluid, and imaging can show fluidfluid levels.Enhancement of the septa and solid components may be observed.Surgical resection of the lesion is curative.

Conclusion
Imaging diagnosis and differential diagnostic considerations for Non-malignant prostatic and SV lesions are broad.Along with the imaging findings, we must consider the clinical context, past medical history, treatment history, current symptoms, age of the patient, clinical examination findings, and serum PSA level to provide an accurate diagnosis and logical differential diagnosis.Knowledge of these conditions can help us identify or suspect entities that may mimic clinically significant prostate cancer on mpMRI in the appropriate clinical setting.

Fig. 1 A
Fig. 1 A 73-year-old man with lower urinary tract symptoms.Axial (A) and sagittal (B) transrectal ultrasound images showing enlargement of the bilateral transition zone with heteroechoic benign prostatic hyperplasia nodules (arrowheads).

Fig. 2 A
Fig.2A 66-year-old male with lower urinary tract symptoms.T2 image in the axial plane (A) showing an enlarged transition zone with few wellencapsulated (arrowhead) and partly encapsulated (arrow) benign prostatic hyperplasia nodules.These nodules can be hyperintense if the glandular element predominates or hypointense if the stromal element predominates.The admixture of these nodules creates an "organized chaos" pattern.Diffusion-weighted imaging at b1500 (B) and apparent diffusion coefficient map (C) showing parts of this nodule showing restricted diffusion.Postcontrast image (D) showing early enhancement of these nodules.

(
PIRADS 2).Diffusion-weighted imaging (DWI) helps in differentiating BPH nodules from prostate cancer, as they do not show marked restricted diffusion on high b Value DWI (b 1400) or marked hypointensity on apparent diffusion coefficient (ADC) images.On dynamic contrast-enhanced MRI (DCE-MRI), BPH nodules may show early enhancement, hence it is unreliable.Although BPH nodules typically occur in TZ, exophytic or extruded BPH nodules can be seen in the peripheral zone (►Fig.3)or central zone 3 and share a similar MRI appearance.►Table 1 shows the types of BPH based on ultrasound and MRI findings.

Fig. 3
Fig. 3 Extruded nodules in two different patients.Axial (A) and sagittal (B) T2-weighted magnetic resonance imaging (MRI) of the prostate in a 64-year-old man with an enlarged prostate and raised prostate-specific antigen (9.65ng/mL) showing benign prostatic hyperplasia (BPH) changes in the transition zone with retrourethral protrusion into the bladder.There is an extruded BPH nodule seen in the left posteromedial peripheral zone of the gland (arrowheads in A and B).Axial (C) and sagittal (D) T2-weighted MRIs of the prostate in another 75-year-old male who had transurethral resection of the prostate previously showing a well-encapsulated extruded heterogeneous nodule in the central zone of the gland (white arrows).

Fig. 4
Fig.4Transrectal ultrasound (TRUS) performed for a patient in sepsis shows enlarged prostate with irregular hypo echoic area (A) representing abscess.There is hyper-vascularity noted at the periphery of the gland (B) suggestive of prostatitis.

Fig. 5 A
Fig. 5 A 61-year-old male with sepsis.(A, B) Axial computed tomography (CT) image showing irregular branching hypodense collections in the prostate and seminal vesicles (arrowheads) with periprostatic fat stranding.There is a contiguous thickening of the bladder base.(C) Selected high-resolution CT images of the same patient showed multiple septic emboli in the lungs seen as cavitating nodules (arrowhead).
Fig. 7 A 58-year-old male with prostate-specific antigen (PSA) of 5 IU/mL from elsewhere and a repeat PSA at our center 8 weeks after the previous PSA of 1.64 IU/mL.Multi-parametric magnetic resonance imaging (MRI) of the prostate was done.(A) T2-weighted axial image showed diffuse T2 hypointense signal of the prostate gland.The capsule was smooth and there was no seminal vesicle involvement.(B, C) Diffusionweighted imaging showed diffusely hyperintense prostate gland on b-1500 image and low signal on apparent diffusion coefficient map suggestive of diffusion restriction.(D, E) Select images of dynamic contrast-enhanced MRI have shown diffuse intense enhancement of the prostate gland.(F) Transrectal ultrasound -guided biopsy showed prostatic parenchyma with aggregates of epithelioid histiocytes forming discrete granulomas (hematoxylin and eosin x 100).

Fig. 9
Fig. 9 Incidentally detected ejaculatory duct cyst in 48-year-old gentleman for the evaluation of rectal polyp.Axial (A) and sagittal (B) high-resolution T2-weighted magnetic resonance imagings showing a left paramedian cyst (arrowhead) in the central zone along the ejaculatory duct above the level of verumontanum.

Fig. 10 (
Fig. 10 (A, B): A 62-year-old gentleman with bladder outlet obstruction symptoms.Trans-abdominal ultrasound (A) and transrectal ultrasound (B) showing an enlarged prostate with an anechoic lesion in the left transition zone in the midgland level (arrowhead) likely cystic degeneration of benign prostatic hyperplasia.(C) Axial high-resolution T2 magnetic resonance imaging showing a well-defined unilocular cyst in the right posterolateral peripheral zone(arrowhead) at mid-gland level that was incidentally detected in a patient with left renal agenesis suggestive of a prostate retention cyst.

Fig. 11 A
Fig. 11 A 33-year-old gentleman with infertility.Coronal (A) high-resolution T2-weighted (T2W) image of the abdomen showing left renal agenesis (arrowhead), and axial (B) high-resolution T2W magnetic resonance image of the pelvis showing ipsilateral seminal vesicle cyst (arrowhead) indenting the left posterior wall of the urinary bladder, suggestive of Zinner syndrome.

Fig. 12
Fig. 12 Incidentally detected Cowper's duct cyst in a 38-year-old gentleman with rectal bleeding.Axial (A), coronal (B), and sagittal (C) high-resolution T2-weighted images of the prostate showing a small ovoid hyperintense lesion at the base of the penile urethra, posterior to the posterior urethra and inferior to the prostate apex.

Fig. 13
Fig. 13 Mimics of prostatic and periprostatic cysts.(A, B) A 72-year-old with post-transurethral resection of the prostate (TURP) status.Axial (A) and coronal (B) high-resolution T2-weighted images showing post-TURP defect (arrowhead).Axial computed tomography (C) images of a 62year-old gentleman showing a large urinary bladder diverticulum along left lateral aspect of the bladder (arrowhead), which shows communication (D) with the urinary bladder(arrowhead).

Fig. 14
Fig. 14 Stromal tumor of uncertain malignant potential (STUMP) in a 66-year-old male.T2 image in axial (A), sagittal (B), and coronal (C) planes showing a well-circumscribed solid-cystic lesion arising from the posterior peripheral zone of the prostate gland with a rim-like T2 hypo-intense "capsule" (arrowhead in B and C).The T1 image in the axial plane (D) showing that the cystic areas are T1 hyperintense suggesting blood products (arrow in D).Apparent diffusion coefficient map (E) showing no diffusion restriction.Histopathology microphotograph (F) confirms the diagnosis of STUMP showing complex branching glands and increased stromal cellularity (hematoxylin and eosin x 40).

Fig. 15 A
Fig. 15 A 44-year-old male with a palpable paraumbilical mass on clinical examination.(A-C) Oblique sagittal, oblique coronal, and axial computed tomographic images of a well-marginated, and pedunculated solid lesion arising from the left seminal vesicle showing heterogeneous enhancement with no invasion to adjacent structures.(D) High-resolution T2 axial images showed that the lesion is predominantly T2 hypointense.(E) Histopathology confirmed the diagnosis of leiomyoma of the seminal vesicle with fascicles of spindle cells with eosinophilic cytoplasm, blunt-ended oval nuclei, and minimal to no cytological atypia (hematoxylin and eosin x 100).

Fig. 16 A
Fig. 16 A 53-year-old male with acute painless urinary retention and an enlarged firm nontender prostate gland, on clinical examination.Prostate-specific antigen was 0.88 IU/mL.Multiparametric magnetic resonance imaging of the prostate.T2-weighted images in axial (A) and coronal (B) planes showed a well-defined lesion from the prostate with heterogeneously hypointense signal intensity.Diffusion-weighted imaging with b 1500 (C) and apparent diffusion coefficient (D) images showed areas of restricted diffusion.Delayed postcontrast subtraction image (E) reveals gradual enhancement.Histopathology microphotograph (F) diagnosed it to be a solitary fibrous tumor with variable cellularity, and dense hyalinized collagenous stroma (hematoxylin and eosin x 200).The tumor cells stained positive for STAT6 (Inset image in F).

Fig. 17
Fig. 17Ectopic prostate tissue in a patient who presented with right flank pain.T2 axial image showing concentric thickening (arrowhead) of the right terminal ureter.This was diagnosed to be prostate parenchyma on cystoscopy and biopsy.(This case was contributed by Prof. Mukesh Harisinghani, MGH, USA).
Fig. 17Ectopic prostate tissue in a patient who presented with right flank pain.T2 axial image showing concentric thickening (arrowhead) of the right terminal ureter.This was diagnosed to be prostate parenchyma on cystoscopy and biopsy.(This case was contributed by Prof. Mukesh Harisinghani, MGH, USA).

Fig. 18
Fig. 18 Prostate cystadenoma in a 40-year-old male.T2 image in axial (A) and sagittal (B) planes showing a well-encapsulated multiloculated cystic lesion (arrowheads in A and B) in the transition zone of the prostate with no solid areas.A small prostatic utricle cyst is seen in the posterior peripheral zone in the midline (arrow in A).

Fig. 19
Fig. 19 Seminal vesicle cystadenoma in a 57-year-old male.T2 images in the axial (A) and sagittal (B) planes and T1 images in the axial (C) plane showing a large encapsulated multiloculated cystic mass with no solid areas from the left seminal vesicle.The prostate is seen separately (arrowhead).The loculi of the tumor showing varying T1 and T2 signal intensities (arrows).Histopathology microphotograph (D) confirms the diagnosis and shows cyst wall and papillary structures lined by a single layer of cells (hematoxylin and eosin x 40).

Table 2
Imaging differences between prostatic utricle cysts and Müllerian duct cysts

Table 3
Differentiating features of various mimickers of prostatic and periprostatic cysts