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Horm Metab Res 1985; 17(2): 78-81
DOI: 10.1055/s-2007-1013456
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© Georg Thieme Verlag, Stuttgart · New York

Effect of Dietary Calcium and Phosphorus Depletion on Vitamin D Metabolism and Calcium Binding Protein in the Growing Pig

B. A. Sommerville, E. Maunder, R. Ross, A. D. Care, R. C. Brown1
  • Department of Animal Physiology and Nutrition, University of Leeds, United Kingdom
  • 1Welsh National School of Medicine, Heath Park, Cardiff, United Kingdom
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Publication History

1983

1983

Publication Date:
14 March 2008 (online)

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Summary

Twenty-four young pigs were divided into three groups and each fed a replete, low calcium (Ca) or low phosphorus (P) diet. It was found that the deficient diets induced rises in renal 25 hydroxy-vitamin D 1,hydroxylase (1-hydroxylase) activity, circulating 1,25 dihydroxy-vitamin D3 (1,25 (OH)2-D3) and Ca binding protein (CaBP) and intestinal 1,25(OH)2D3 and CaBP. All these rises were statistically significant in the low Ca group but only the rises in the 1-hydroxylase activity and intestinal 1,25(OH)2D3 were significant in the low P group. A high degree of correlation existed between the parameters. There was no enhancement of intestinal 1,25(OH)2D3 or CaBP concentration relative to the 1-hydroxylase activity in the low P pigs as occurs in the chick. The low-P-induced rise in 1-hydroxylase activity was independent of parathyroid hormone.

Key-Words:

Pig - Vitamin D - Ca-Binding Protein - Ca and P Depletion

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