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Thromb Haemost 2015; 113(02): 221-230
DOI: 10.1160/TH14-05-0449
Current Opinion
Schattauer GmbH

Platelet function testing in acute cardiac care – is there a role for prediction or prevention of stent thrombosis and bleeding?

Dániel Aradi
1   Department of Cardiology, Heart Center Balatonfüred, Hungary
5   Heart and Vascular Center, Semmelweis University, Budapest, Hungary
,
Jean-Philippe Collet
2   ACTION Study Group-Institut de Cardiologie – INSERM UMRS-ICAN 1166 Groupe Hospitalier Pitié-Salpêtrière, Paris, France
,
Johannes Mair
3   Department of Internal Medicine III – Cardiology and Angiology, Innsbruck Medical University, Innsbruck, Austria
,
Mario Plebani
4   Department of Laboratory Medicine, University_Hospital, Padova, Italy
,
Béla Merkely
5   Heart and Vascular Center, Semmelweis University, Budapest, Hungary
,
Allan S. Jaffe
6   Division of Cardiovascular Diseases, Department of Medicine and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
,
Martin Möckel
7   Emergency Medicine and Chest Pain Units, Campus Virchow-Klinikum und Campus Mitte Charité – Universittsmedizin Berlin, Germany
,
Evangelos Giannitsis
8   8Department of Internal Medicine III – University of Heidelberg, Germany
,
Kristian Thygesen
9   Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
,
Jurrien M. ten Berg
10   Department of Cardiology and Center of Platelet Function Research, St Antonius Hospital, Nieuwegein, the Netherlands;
,
Christian Mueller
11   Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland
,
Robert F. Storey
12   Department of Cardiovascular Science, University of Sheffield, Sheffield, UK
,
Bertil Lindahl
13   Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Sweden
,
Kurt Huber
14   3rd Department of Medicine, Cardiology and Intensive Care, Wilhelminenhospital, Vienna, Austria
› Author Affiliations Financial support: This work was supported by the Association for the Promotion of Research on Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB), Viennna, Austria to KH and by a research grant from the Hungarian Academy of Sciences to DA.
Further Information

Publication History

Received: 20 May 2014

Accepted after major revision: 05 September 2014

Publication Date:
27 November 2017 (online)

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Summary

The role of platelet function testing in acute coronary syndrome patients undergoing percutaneous coronary intervention remains controversial despite the fact that high platelet reactivity is an independent predictor of stent thrombosis and emerging evidence suggests also a link between low platelet reactivity and bleeding. In this expert opinion paper, the Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association and the Working Group on Thrombosis of the European Society of Cardiology aim to provide an overview of current evidence in this area and recommendations for practicing clinicians.

Keywords

Antiplatelet agents - platelet pharmacology - acute myocardial infarction
 

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