Reinke’s edema

A unique imaging dilemma is presented where vocal fold thickening due to Reinke’s edema mimicked tumor invasion of the vocal cords in a known case of thyroid malignancy.


Introduction
Computed tomography of the neck is routinely performed in neck malignancies for disease staging.Soft tissue thickening of the vocal folds in the presence of an adjacent extralaryngeal malignancy is a worrying observation; however, it does not always signify laryngeal invasion, as is highlighted in the following case.

Case Report
A 51-year-old man presented with a midline neck swelling and chronic hoarseness.On examination, a large prelaryngeal mass with a left level III lymphadenopathy was seen.1].Ultrasonography of the neck showed a midline, solid, heterogeneous mass arising from the thyroid isthmus with extrathyroidal extension into the strap muscles and thyroid cartilages and a large left level III metastatic lymph node.CT scan revealed diff use inÞ ltration of the paraglott ic fat, which was suspicious of tumor inÞ ltration [Figure 2].However the thyroid and cricoid cartilages did not show any features of destruction.Biopsy of the mass revealed poorly diff erentiated small cell carcinoma of the thyroid.

Laryngoscopy revealed edematous vocal cords with diminished vibrations [Figure
At surgery, a large mass was seen arising from the isthmus and adjacent areas of both lobes, with extrathyroidal spread into the strap muscles and the anterior perichondrium of the thyroid cartilage; it was abutt ing the cricothyroid membrane.Multiple, enlarged, bilateral lymph nodes were seen.The patient underwent total thyroidectomy with excision of the strap muscles and bilateral modiÞ ed neck dissection.
Histopathology of the resected specimen conÞ rmed the preoperative diagnosis of poorly diff erentiated (insular) carcinoma of thyroid.

Discussion
Reinke's space [1] is the subepithelial matrix of the vocal fold mucosa composed of elastin, collagen and other extracellular proteins; it is also known as the superÞ cial lamina propria [Figure 3].Reinke's edema is the accumulation of ß uid in this space.T he condition is fairly common and constitutes about 10% of benign laryngeal lesions. [2]ndian J Radiol Imaging / November 2009 / Vol 19 / Issue 4 The edema develops by degrees, as a nonspeciÞ c reaction of the vocal folds to various irritative noxious agents.The main risk factor has been found to be cigarett e smoking. [3]ther factors are chronic voice abuse, allergy, infection and laryngopharyngeal reß ux; chronic sinusitis has also been implicated, though the association is not as noteworthy.Reinke's edema prevents normal vocal cord vibrations, giving rise to a hoarse, low-pitched voice.
Edematous swelling of the vocal cords can be easily recognized on indirect laryngoscopy, when the vocal cords are seen to be red and swollen and to have a slightly translucent appearance. [2]The reason this condition is important for radiologists, is that the presence of bilateral vocal cord edema on CT scan, may mimic cord involvement from adjacent malignancies, as in this present case, where the soft tissue raised the suspicion of tumor inÞ ltration.This possibility in any case seemed unlikely in view of the preservation of the thyroid cartilage.However, the laryngoscopic Þ ndings were conÞ rmatory and allowed us to conÞ dently rule out cord involvement and to explain the cord thickening to be due to Reinke's edema.
To conclude, imaging is not required to diagnose Reinke's edema, as the diagnosis is evident on laryngoscopy.Nevertheless, it is important for the radiologist to be aware of this entity as the soft tissue thickening produced by Reinke's edema can be easily mistaken for tumor inÞ ltration of the vocal cords.

Figure 2 :
Figure 2: Axial CT scan at the level of the arytenoid cartilages shows diffuse soft tissue thickening of the vocal folds and paraglottic fat (arrows).The superior pole of the thyroid neoplasm is noted (arrowhead).Note that there is no evidence of thyroid cartilage invasion (curved arrows)