Planta Med 2012; 78(3): 269-275
DOI: 10.1055/s-0031-1280454
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Diterpenoids Including a Novel Dimeric Conjugate from Salvia leriaefolia

Muhammad Iqbal Choudhary1 , 2 , Amjad Hussain1 , Zulfiqar Ali2 , 3 , Achyut Adhikari1 , Samina A. Sattar1 , Syed A. Majid Ayatollahi4 , Abdullah M. A. Al-Majid2 ,  Atta-ur-Rahman1
  • 1H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
  • 2Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
  • 3National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, USA
  • 4Phytochemistry Research Center and Department of Pharmacognosy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
Further Information

Publication History

received Sept. 8, 2011 revised Nov. 1, 2011

accepted Nov. 28, 2011

Publication Date:
15 December 2011 (eFirst)

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Abstract

Salvialeriafone (1), a novel diterpene-norditerpene conjugate, was isolated from Salvia leriaefolia. Additionally, two new abietane-type diterpenoids, salvialerial (2) and salvialerione (3), as well as four known compounds, sugiol (4), salvicanaric acid (5), dehydroroyleanone (6), and cariocal (7), were isolated and identified. Their structures were determined by spectroscopic data analyses. Known compounds were isolated from this plant for the first time. Compounds 1, 5, 6, and 7 exhibited in vitro antiproliferative activity against the human cervical cancer cell line (Hela), while 6 showed cytotoxicity against the human prostate cancer cell line (PC3).

Key words

Salvia leriaefolia - Labiatae - abietane diterpenoids - salvialeriafone - salvialerial - salvialerione - antiproliferative effect