Neuroprotective Potential of Ginkgo biloba in Retinal Diseases

Isabel Martínez-Solís; Nuria Acero; Francisco Bosch-Morell; Encarna Castillo; María Eugenia González-Rosende; Dolores Muñoz-Mingarro; Teresa Ortega; María Amparo Sanahuja; Victoria Villagrasa

doi:10.1055/a-0947-5712

Planta Medica, Inhaltsverzeichnis

Planta Med 2019; 85(17): 1292-1303
DOI: 10.1055/a-0947-5712

Biological and Pharmacological Activity

Reviews

Georg Thieme Verlag KG Stuttgart · New York

Neuroprotective Potential of Ginkgo biloba in Retinal Diseases

Autor*innen

Isabel Martínez-Solís

¹Biomedical Sciences Institute, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain

²Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain

³Botanical Garden, University of Valencia, Valencia, Spain
Nuria Acero

⁴Department of Pharmaceutical and Health Sciences, Faculty of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain
Francisco Bosch-Morell

¹Biomedical Sciences Institute, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain

⁵Department of Biomedical Sciences, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain
Encarna Castillo

²Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain
María Eugenia González-Rosende

²Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain
Dolores Muñoz-Mingarro

⁶Department of Chemistry and Biochemistry, Faculty of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain
Teresa Ortega

⁷Department of Pharmacology and Botany. Universidad Complutense de Madrid, Madrid, Spain
María Amparo Sanahuja

²Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain
Victoria Villagrasa

²Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain

Abstract

Like other tissues of the central nervous system, the retina is susceptible to damage by oxidative processes that result in several neurodegenerative disease such as age-related macular degeneration, diabetic retinopathy, glaucoma, ischaemic retinal disease, retinal disease produced by light oxidation, and detached retina, among other diseases. The use of antioxidant substances is a solution to some health problems caused by oxidative stress, because they regulate redox homeostasis and reduce oxidative stress. This is important for neurodegeneration linked to oxidation processes. In line with this, Ginkgo biloba is a medicinal plant with excellent antioxidant properties whose effects have been demonstrated in several degenerative processes, including retinal diseases associated with neurodegeneration. This review describes the current literature on the role of ginkgo in retinal diseases associated with neurodegeneration. The information leads to the conclusion that G. biloba extracts might be a good option to improve certain neurodegenerative retinal diseases, but more research is needed to determine the safety and efficacy of G. biloba in these retinal degenerative processes.

Key words

Ginkgo biloba - Ginkgoaceae - neurodegeneration - retinal diseases - age-related macular degeneration - diabetic retinopathy - glaucoma - ischaemic retinal disease

Volltext

Referenzen

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