Cardiac Biomarker Response to Intermittent Exercise Bouts

Abstract

The impact of intermittent exercise on cardiac biomarker release has not been clearly established. In experienced athletes, we examined the acute effect of a heavy resistance training session (n=18 males) and an indoor soccer match (n=21, 11 males, 10 females) on the release of cTnI, cTnT, and NT-proBNP. Biomarkers were assayed from blood samples collected at rest, immediately post- and at 1, 3, 6, 12, and 24 h post-exercise. The heavy resistance training session resulted in an increase in NT-proBNP (pre: 15±17, peak post: 41±56 ng L⁻¹; p=0.001) but not in cTnI (pre: 0.024±0.009, peak post: 0.025±0.011 μg L⁻¹, p=0.809) or cTnT (undetectable in all samples). The indoor soccer match led to an increase in the release of NT-proBNP (pre: 28±32, peak post: 66±56 ng L⁻¹; p=0.000) and cTnI (pre: 0.026±0.047, peak post: 0.033±0.051 μg L⁻¹; p=0.008) in both males and females but not cTnT (detectable in only one subject). The current data suggest that intermittent bouts of exercise result in only modest perturbations of cardiac biomarkers with very limited evidence of myocyte injury/insult.

soccer - weightlifting - cTnT - cTnI - NT-proBNP

References

• 1 Al-Barjas M, Nair D, Ayrton P, Morris R, Davar J. How can the role of N terminal pro B Natriuretic Peptide (NT-proBNP) be optimised in heart failure screening? A prospective obsevational comparative study.  Eur Heart J Fail. 2004;  3 51 Supplement 1
• 2 Barbero-Alvarez JC, Soto VM, Barbero-Alvarez V, Granda-Vera J. Match analysis and heart rate of futsal players during competition.  J Sports Sci. 2008;  26 63-73
• 3 Collinson PO, Barnes SC, Gaze DC, Galasko G, Lahiri A, Senior R. Analytical performance of the N terminal pro B type natriuretic peptide (NT-proBNP) assay on the Elecsys 1010 and 2010 analysers.  Eur J Heart Fail. 2004;  6 365-368
• 4 Collinson PO, Boa FG, Gaze DC. Measurement of cardiac troponins.  Ann Clin Biochem. 2001;  38 ((Pt 5)) 423-449
• 5 Eggers KM, Lagerqvist B, Venge P, Wallentin L, Lindahl B. Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality.  Circulation. 2007;  116 1907-1914
• 6 Eijsvogels T, George K, Shave R, Gaze D, Levine BD, Hopman MT, Thijssen DH. Effect of prolonged walking on cardiac troponin levels.  Am J Cardiol. 2010;  105 267-272
• 7 Fu F, Nie J, Tong TK. Serum cardiac troponin T in adolescent runners: effects of exercise intensity and duration.  Int J Sports Med. 2009;  30 168-172
• 8 George KP, Dawson E, Shave RE, Whyte G, Jones M, Hare E, Gaze D, Collinson P. Left ventricular systolic function and diastolic filling after intermittent high intensity team sports.  Br J Sports Med. 2004;  38 452-456
• 9 Gotshalk LA, Loebel CC, Nindl BC, Putukian M, Sebastianelli WJ, Newton RU, Häkkinen K, Kraemer WJ. Hormonal responses of multiset versus single-set heavy-resistance exercise protocols.  Can J Appl Physiol. 1997;  22 244-255
• 10 Harriss DJ, Atkinson G. International Journal of Sports Medicine – Ethical Standards in Sport and Exercise Science Research.  Int J Sports Med. 2009;  30 701-702
• 11 Herrmann M, Scharhag J, Miclea M, Urhausen A, Herrmann W, Kindermann W. Post-race kinetics of cardiac troponin T and I and N-terminal pro-brain natriuretic peptide in marathon runners.  Clin Chem. 2003;  49 831-834
• 12 Middleton N, George KP, Whyte GP, Gaze D, Collinson P, Shave R. Cardiac Troponin T release is stimulated by endurance exercise in healthy humans.  J Am Coll Cardio. 2008;  52 1813-1814
• 13 Neilan TG, Januzzi JL, Lee-Lewandrowski E, Ton-Nu TT, Yoerger DM, Jassal DS, Lewandrowski KB, Siegel AJ, Marshall JE, Douglas PS, Lawlor D, Picard MH, Wood MJ. Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon.  Circulation. 2006;  114 2325-2333
• 14 Nie J, Tong TK, Shi Q, Lin H, Zhao J, Tian Y. Serum cardiac troponin response in adolescents playing basketball.  Int J Sports Med. 2008;  29 449-452
• 15 Sahlén A, Winter R, Lind B, Jacobsen PH, Ståhlberg M, Marklund T, Fux T, Svensson J, Braunschweig F. Magnitude, reproducibility, and association with baseline cardiac function of cardiac biomarker release in long-distance runners aged ≥ 55 years.  Am J Cardiol. 2008;  102 218-222
• 16 Scharhag J, George K, Shave R, Urhausen A, Kindermann W. Exercise-associated increases in cardiac biomarkers.  Med Sci Sports Exerc. 2008;  40 1408-1415
• 17 Scharhag J, Herrmann M, Urhausen A, Haschke M, Herrmann W, Kindermann W. Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise.  Am Heart J. 2005;  150 1128-1134
• 18 Scott JM, Esch BT, Shave R, Warburton DE, Gaze D, George K. Cardiovascular consequences of completing a 160-km ultramarathon.  Med Sci Sports Exerc. 2009;  41 26-34
• 19 Serrano-Ostáriz E, Legaz-Arrese A, Terreros-Blanco JL, López-Ramón M, Cremades-Arroyos D, Carranza-García LE, Izquierdo-Alvarez S, Bocos-Terraz P. Cardiac biomarkers and exercise duration and intensity during a cycle-touring event.  Clin J Sport Med. 2009;  19 293-299
• 20 Serrano-Ostáriz E, Terreros-Blanco JL, Legaz-Arrese A, George K, Shave R, Bocos-Terraz P, Izquierdo-Álvarez S, Bancalero JL, Echavarri JM, Quilez J, Aragonés MT, Carranza-García LE. The impact of exercise duration and intensity on the release of cardiac biomarkers.  Scand J Med Sci Sports. 2009;  Nov 17 DOI: doi: 10.1111/j.1600-0838.2009.01042.x
• 21 Shave R, George K, Gaze D. The influence of exercise upon cardiac biomarkers: A practical guide for clinicians and scientists.  Curr Med Chem. 2007;  14 1427-1436
• 22 Shave R, George KP, Atkinson G, Hart E, Middleton N, Whyte G, Gaze D, Collinson PO. Exercise-induced cardiac troponin T release: a meta-analysis.  Med Sci Sports Exerc. 2007;  39 2099-2106
• 23 Shave R, Ross P, Low D, George K, Gaze D. Cardiac troponin I is released following high-intensity short-duration exercise in healthy humans.  Int J Cardiol. 2010;  145 337-339
• 24 Stephenson C, McCarthy J, Vikelis E, Shave R, Whyte G, Gaze D, George K. Effect of weightlifting upon left ventricular function and markers of cardiomyocyte damage.  Ergonomics. 2005;  48 1585-1593
• 25 Vidotto C, Tschan H, Atamaniuk J, Pokan R, Bachl N, Müller MM. Responses of N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) to competitive endurance exercise in recreational athletes.  Int J Sports Med. 2005;  26 645-650

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