ABSTRACT
The intrauterine growth restricted (IUGR) fetus develops unique metabolic adaptations
in response to exposure to reduced nutrient supply. These adaptations provide survival
value for the fetus by enhancing the capacity of the fetus to take up and use nutrients,
thereby reducing the need for nutrient supply. Each organ and tissue in the fetus
adapts differently, with the brain showing the greatest capacity for maintaining nutrient
supply and growth. Such adaptations, if persistent, also have the potential in later
life to promote nutrient uptake and storage, which directly lead to complications
of obesity, insulin resistance, reduced insulin production, and type 2 diabetes.
KEYWORDS
Fetus - placenta - pregnancy - intrauterine growth restriction (IUGR) - nutrition
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William W HayJr.
Professor of Pediatrics, University of Colorado School of Medicine, Perinatal Research
Center
F441, 13243 East 23rd Avenue, Aurora, CO 80045
eMail: bill.hay@ucdenver.edu
