Medullary Thyroid Nodules by Measurement of Calcitonin (Ct) in Aspiration Needle Washout in Patients with Multinodular Goiter and Moderately Elevated Serum Ct

P. Trimboli; G. Nigri; F. Romanelli; D. D. Cicciarella Modica; A. Crescenzi; S. Valabrega; L. Giovanella

doi:10.1055/s-0031-1291344

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2012; 120(04): 234-237
DOI: 10.1055/s-0031-1291344

Article

Medullary Thyroid Nodules by Measurement of Calcitonin (Ct) in Aspiration Needle Washout in Patients with Multinodular Goiter and Moderately Elevated Serum Ct

Autoren

P. Trimboli

¹Section of Endocrinology and Diabetology, Ospedale Israelitico, Rome, Italy
G. Nigri

²Sapienza University 2nd School of Medicine ,Ospedale S. Andrea, Rome, Italy
F. Romanelli

³Department of Experimental Medicine, Sapienza University, Rome, Italy
D. D. Cicciarella Modica

⁴Section of Pathology, Ospedale Israelitico, Rome, Italy
A. Crescenzi

⁴Section of Pathology, Ospedale Israelitico, Rome, Italy
S. Valabrega

²Sapienza University 2nd School of Medicine ,Ospedale S. Andrea, Rome, Italy
L. Giovanella

⁵Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

Abstract

The accuracy of fine needle aspiration cytology (FNAC) is low in medullary thyroid carcinomas (MTC). Recently, a few papers analyzed the measurement of calcitonin (Ct) in washout of the needle after aspiration (WO-Ct) suggesting that this approach may be useful in patients with high serum Ct.

Here we reported, for the first time in our best knowledge, 3 patients with multinodular goiter, moderately elevated serum Ct, high value of WO-Ct, and medullary outcome. These findings suggest that in presence of high serum Ct, FNAC should be performed in all nodules, and it should be combined with WO-Ct in all cases.

Key words

medullary thyroid carcinoma - calcitonin - washout measurement - fine needle aspiration

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References
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