Abstract
The small noncoding RNAs, microRNAs (or miRNAs), have been implicated in a myriad
of diseases and accumulating evidence indicate their potential high value as diagnostic
biomarkers. Although their roles in hemostasis and coagulation pathways are less defined,
many studies have demonstrated their participation in regulating key factors of hemostasis.
However, the mounting challenges associated with the accurate measurement of circulating
miRNAs and the involvement of platelet activation in contributing to the circulating
miRNA expression profile introduce further complexity to the study of thrombosis-associated
miRNAs. This review outlines the current knowledge of miRNAs that have been postulated
to regulate key hemostatic factors, and miRNA diagnostic panels in thrombotic disease,
with a focus on experimental fundamentals, such as selecting condition-specific reference
controls, considerations that are crucial for accurate evaluation of miRNAs in the
context of disease biomarkers.
Keywords
microRNAs - thrombosis - circulating miRNAs - miR-494 - biomarkers
