Prevalence of the Factor II G20210A Mutation in Symptomatic Patients with Inherited Thrombophilia

Thromb Haemost 1998; 80(02): 342-343
DOI: 10.1055/s-0037-1615199

Letters to the Editor

Schattauer GmbH

Valerio De Stefano

¹Department of Hematology, Catholic University, Rome, Italy

,

Patrizia Chiusolo

¹Department of Hematology, Catholic University, Rome, Italy

,

Katia Paciaroni

¹Department of Hematology, Catholic University, Rome, Italy

,

Ida Casorelli

¹Department of Hematology, Catholic University, Rome, Italy

,

Antonella Di Mario

¹Department of Hematology, Catholic University, Rome, Italy

,

Elena Rossi

¹Department of Hematology, Catholic University, Rome, Italy

,

Giuseppe Leone

¹Department of Hematology, Catholic University, Rome, Italy

References
1 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
2 Makris M, Preston FE, Beauchamp NJ, Cooper PC, Daly ME, Hampton KK, Bayliss P, Peake IR, Miller GJ. Co-inheritance of the 20210A allele of the prothrombin gene increases the risk of thrombosis in subjects with a familial thrombophilia. Thromb Haemost 1997; 78: 1426-9.
3 Alhenc-Gelas M, Le Cam-Duchez V, Emmerich J, Frebourg T, Fiessinger J-N, Borg J-Y, Aiach M. The A20210 allele of the prothrombin gene is not frequently associated with the Factor V Arg 506 to Gln mutation in thrombophilic families. Blood 1997; 90: 1711.